Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis

Myelodysplastic neoplasm (MDS) is a hematopoietic stem cell disorder that may evolve into acute myeloid leukemia. Fatal infection is among the most common cause of death in MDS patients, likely due to myeloid cell cytopenia and dysfunction in these patients. Mutations in genes that encode components...

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Detalles Bibliográficos
Autores principales: Gurule, Natalia J., Malcolm, Kenneth C., Harris, Chelsea, Knapp, Jennifer R., O’Connor, Brian P., McClendon, Jazalle, Janssen, William J., Lee, Frank Fang Yao, Price, Caitlin, Osaghae-Nosa, Jackson, Wheeler, Emily A., McMahon, Christine M., Pietras, Eric M., Pollyea, Daniel A., Alper, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539173/
https://www.ncbi.nlm.nih.gov/pubmed/37591942
http://dx.doi.org/10.1038/s41375-023-02007-7

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