Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab

We report a case of a 38-year-old man who developed a nephrotic syndrome shortly after the start of guselkumab for the treatment of plaque psoriasis. Renal biopsy showed focal segmental glomerulosclerosis (FSGS). The clinical course of our case is highly suspect for drug-induced FSGS since the nephr...

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Autores principales: Stryckers, Marijke, Van Oevelen, Stefaan, Koshy, Priyanka, Sprangers, Ben, Van Craenenbroeck, Amaryllis H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Exceptional Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539213/
https://www.ncbi.nlm.nih.gov/pubmed/37779841
http://dx.doi.org/10.1093/ckj/sfad161
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author Stryckers, Marijke
Van Oevelen, Stefaan
Koshy, Priyanka
Sprangers, Ben
Van Craenenbroeck, Amaryllis H
author_facet Stryckers, Marijke
Van Oevelen, Stefaan
Koshy, Priyanka
Sprangers, Ben
Van Craenenbroeck, Amaryllis H
author_sort Stryckers, Marijke
collection PubMed
description We report a case of a 38-year-old man who developed a nephrotic syndrome shortly after the start of guselkumab for the treatment of plaque psoriasis. Renal biopsy showed focal segmental glomerulosclerosis (FSGS). The clinical course of our case is highly suspect for drug-induced FSGS since the nephrotic syndrome resolved after cessation of the drug without relapse (2 years of follow-up). To the best of our knowledge, this is the first case describing FSGS lesions associated with the use of an interleukin-23 inhibitor.
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spelling pubmed-105392132023-09-30 Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab Stryckers, Marijke Van Oevelen, Stefaan Koshy, Priyanka Sprangers, Ben Van Craenenbroeck, Amaryllis H Clin Kidney J Exceptional Case We report a case of a 38-year-old man who developed a nephrotic syndrome shortly after the start of guselkumab for the treatment of plaque psoriasis. Renal biopsy showed focal segmental glomerulosclerosis (FSGS). The clinical course of our case is highly suspect for drug-induced FSGS since the nephrotic syndrome resolved after cessation of the drug without relapse (2 years of follow-up). To the best of our knowledge, this is the first case describing FSGS lesions associated with the use of an interleukin-23 inhibitor. Oxford University Press 2023-07-06 /pmc/articles/PMC10539213/ /pubmed/37779841 http://dx.doi.org/10.1093/ckj/sfad161 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Exceptional Case
Stryckers, Marijke
Van Oevelen, Stefaan
Koshy, Priyanka
Sprangers, Ben
Van Craenenbroeck, Amaryllis H
Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab
title Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab
title_full Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab
title_fullStr Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab
title_full_unstemmed Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab
title_short Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab
title_sort focal segmental glomerulosclerosis associated with the use of the il-23 inhibitor guselkumab
topic Exceptional Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539213/
https://www.ncbi.nlm.nih.gov/pubmed/37779841
http://dx.doi.org/10.1093/ckj/sfad161
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