Cargando…

Menthol- and thymol-based ciprofloxacin derivatives against Mycobacterium tuberculosis: in vitro activity, lipophilicity, and computational studies

In this work, we investigated the antitubercular properties of Ciprofloxacin derivatives conjugated with menthol and thymol moieties. For the sixteen derivatives, we established minimal inhibitory concentrations (MIC) using isolates of Mycobacterium tuberculosis that were resistant or susceptible to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Szulczyk, Daniel, Woziński, Mateusz, Koliński, Michał, Kmiecik, Sebastian, Głogowska, Agnieszka, Augustynowicz-Kopeć, Ewa, Dobrowolski, Michał A., Roszkowski, Piotr, Struga, Marta, Ciura, Krzesimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539350/ https://www.ncbi.nlm.nih.gov/pubmed/37770610 http://dx.doi.org/10.1038/s41598-023-43708-4

Ejemplares similares

Design and Synthesis of Menthol and Thymol Derived Ciprofloxacin: Influence of Structural Modifications on the Antibacterial Activity and Anticancer Properties
por: Szostek, Tomasz, et al.
Publicado: (2022)

The Effect of Conjugation of Ciprofloxacin and Moxifloxacin with Fatty Acids on Their Antibacterial and Anticancer Activity
por: Chrzanowska, Alicja, et al.
Publicado: (2022)

N-Acylated Ciprofloxacin Derivatives: Synthesis and In Vitro Biological Evaluation as Antibacterial and Anticancer Agents
por: Struga, Marta, et al.
Publicado: (2023)

Novel Tetrazole-Based Antimicrobial Agents Targeting Clinical Bacteria Strains: Exploring the Inhibition of Staphylococcus aureus DNA Topoisomerase IV and Gyrase
por: Roszkowski, Piotr, et al.
Publicado: (2021)

Synthetic Transition from Thiourea-Based Compounds to Tetrazole Derivatives: Structure and Biological Evaluation of Synthesized New N-(Furan-2-ylmethyl)-1H-tetrazol-5-amine Derivatives
por: Szulczyk, Daniel, et al.
Publicado: (2021)

6-Bromo-2-methylsulfanyl-1,3-benzothiazole
por: Dobrowolski, Michał A., et al.
Publicado: (2011)

Cytotoxicity Evaluation of Novel bis(2-aminoethyl)amine Derivatives
por: Szulczyk, Daniel, et al.
Publicado: (2020)

Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches
por: Ciura, Krzesimir, et al.
Publicado: (2019)

Thymol, Menthol and Camphor from Indian Sources
por: Chopra, R. N., et al.
Publicado: (1932)

Modeling of Anticancer Sulfonamide Derivatives Lipophilicity by Chemometric and Quantitative Structure-Retention Relationships Approaches
por: Pastewska, Monika, et al.
Publicado: (2022)

Molecular Dynamics Scoring of Protein–Peptide Models Derived from Coarse-Grained Docking
por: Zalewski, Mateusz, et al.
Publicado: (2021)

Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
por: Szulczyk, Daniel, et al.
Publicado: (2013)

Lipophilicity Determination of Antifungal Isoxazolo[3,4-b]pyridin-3(1H)-ones and Their N1-Substituted Derivatives with Chromatographic and Computational Methods
por: Ciura, Krzesimir, et al.
Publicado: (2019)

Structure Prediction of the Second Extracellular Loop in G-Protein-Coupled Receptors
por: Kmiecik, Sebastian, et al.
Publicado: (2014)

Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives
por: Drzewiecka-Antonik, Aleksandra, et al.
Publicado: (2022)

CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site
por: Kurcinski, Mateusz, et al.
Publicado: (2015)

New RAPMYCOI Sensititre(TM) Antimicrobial Susceptibility Test for Atypical Rapidly Growing Mycobacteria (RGM)
por: Borek, Anna, et al.
Publicado: (2022)

CABS-flex predictions of protein flexibility compared with NMR ensembles
por: Jamroz, Michal, et al.
Publicado: (2014)

CABS-flex: server for fast simulation of protein structure fluctuations
por: Jamroz, Michal, et al.
Publicado: (2013)

Mycobacterium szulgai Lung Disease or Breast Cancer Relapse—Case Report
por: Kempisty, Anna, et al.
Publicado: (2020)

Drug Susceptibility of Non-tuberculous Strains of Mycobacterium Isolated from Birds from Poland
por: LEDWOŃ, ALEKSANDRA, et al.
Publicado: (2018)

A Novel Approach to Optimize Hot Melt Impregnation in Terms of Amorphization Efficiency
por: Garbera, Kamil, et al.
Publicado: (2020)

Intracardiac tuberculomas caused by Mycobacterium tuberculosis in a dog
por: Szaluś-Jordanow, Olga, et al.
Publicado: (2016)

CABS-fold: server for the de novo and consensus-based prediction of protein structure
por: Blaszczyk, Maciej, et al.
Publicado: (2013)

Docking of peptides to GPCRs using a combination of CABS-dock with FlexPepDock refinement
por: Badaczewska-Dawid, Aleksandra E, et al.
Publicado: (2020)

Molecular methods in diagnostics of post-BCG vaccine adverse events
por: BRZEZIŃSKA, SYLWIA AGATA, et al.
Publicado: (2020)

Protein–Protein Docking with Large-Scale Backbone Flexibility Using Coarse-Grained Monte-Carlo Simulations
por: Kurcinski, Mateusz, et al.
Publicado: (2021)

Symes on Thymol and Thymol Camphor
Publicado: (1879)

Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampin
por: Zaczek, Anna, et al.
Publicado: (2009)

The Effect of Fatty Acids on Ciprofloxacin Cytotoxic Activity in Prostate Cancer Cell Lines—Does Lipid Component Enhance Anticancer Ciprofloxacin Potential?
por: Chrzanowska, Alicja, et al.
Publicado: (2022)

Experimental Inoculation of BFDV-Positive Budgerigars (Melopsittacus undulatus) with Two Mycobacterium avium subsp. avium Isolates
por: Ledwoń, Aleksandra, et al.
Publicado: (2014)

Phenotypic and genotypic characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients with chronic infections
por: Iwańska, Agnieszka, et al.
Publicado: (2023)

Synthesis and Biological Activity of Piperidinothiosemicarbazones Derived from Aminoazinecarbonitriles
por: Ziembicka, Dagmara, et al.
Publicado: (2023)

Evaluation of Susceptibility to Antimycobacterial Drugs in Mycobacterium Tuberculosis Complex Strains Isolated from Cattle in Poland
por: Krajewska-Wędzina, Monika, et al.
Publicado: (2017)

Inhibitory Effect of Thymol on Tympanostomy Tube Biofilms of Methicillin-Resistant Staphylococcus aureus and Ciprofloxacin-Resistant Pseudomonas aeruginosa
por: Jo, Eu-Ri, et al.
Publicado: (2022)

Thymol
Publicado: (1878)

4-(3-Fluorophenyl)-1-(propan-2-ylidene)thiosemicarbazone
por: Miroslaw, Barbara, et al.
Publicado: (2011)

Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties
por: Szulczyk, Daniel, et al.
Publicado: (2017)

Mycobacterium chimaera as an Underestimated Cause of NTM Lung Diseases in Patients Hospitalized in Pulmonary Wards
por: ZABOST, ANNA T., et al.
Publicado: (2021)

Molecular Characterisation of the Mycobacterium Bovis Causing Bovine Tuberculosis Outbreaks in Poland
por: Krajewska-Wędzina, Monika, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ghpp0n7fjmst5o6m4j3abrooub