Extracellular high molecular weight α-synuclein oligomers induce cell death by disrupting the plasma membrane

α-Synuclein (αS), the causative protein of Parkinson’s disease and other α-synucleinopathies, aggregates from a low molecular weight form (LMW-αS) to a high molecular weight αS oligomer (HMW-αSo). Aggregated αS accumulates intracellularly, induces intrinsic apoptosis, is released extracellularly, an...

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Detalles Bibliográficos
Autores principales: Ito, Naohito, Tsuji, Mayumi, Adachi, Naoki, Nakamura, Shiro, Sarkar, Avijite Kumer, Ikenaka, Kensuke, Aguirre, César, Kimura, Atsushi Michael, Kiuchi, Yuji, Mochizuki, Hideki, Teplow, David B., Ono, Kenjiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539356/
https://www.ncbi.nlm.nih.gov/pubmed/37770475
http://dx.doi.org/10.1038/s41531-023-00583-0

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