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Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century’s plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the b...

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Autores principales: El-Derany, Marwa O., Hanna, Diana M. F., Youshia, John, Elmowafy, Enas, Farag, Mohamed A., Azab, Samar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539420/
https://www.ncbi.nlm.nih.gov/pubmed/37587394
http://dx.doi.org/10.1007/s43440-023-00517-w
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author El-Derany, Marwa O.
Hanna, Diana M. F.
Youshia, John
Elmowafy, Enas
Farag, Mohamed A.
Azab, Samar S.
author_facet El-Derany, Marwa O.
Hanna, Diana M. F.
Youshia, John
Elmowafy, Enas
Farag, Mohamed A.
Azab, Samar S.
author_sort El-Derany, Marwa O.
collection PubMed
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century’s plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the increasing proportion of nano-based vaccines, this review compiles and analyses how COVID-19 and nanoparticles affect lipids, amino acids, and carbohydrates metabolism. A search was conducted on PubMed, ScienceDirect, Web of Science for available information on the interrelationship between metabolomics and immunity in the context of SARS-CoV-2 infection and the effect of nanoparticles on metabolite levels. It was clear that SARS-CoV-2 disrupted several pathways to ensure a sufficient supply of its building blocks to facilitate its replication. Such information can help in developing treatment strategies against viral infections and COVID-19 based on interventions that overcome these metabolic changes. Furthermore, it showed that even drug-free nanoparticles can exert an influence on biological systems as evidenced by metabolomics. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-105394202023-09-30 Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study El-Derany, Marwa O. Hanna, Diana M. F. Youshia, John Elmowafy, Enas Farag, Mohamed A. Azab, Samar S. Pharmacol Rep Review The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently regarded as the twenty-first century’s plague accounting for coronavirus disease 2019 (COVID-19). Besides its reported symptoms affecting the respiratory tract, it was found to alter several metabolic pathways inside the body. Nanoparticles proved to combat viral infections including COVID-19 to demonstrate great success in developing vaccines based on mRNA technology. However, various types of nanoparticles can affect the host metabolome. Considering the increasing proportion of nano-based vaccines, this review compiles and analyses how COVID-19 and nanoparticles affect lipids, amino acids, and carbohydrates metabolism. A search was conducted on PubMed, ScienceDirect, Web of Science for available information on the interrelationship between metabolomics and immunity in the context of SARS-CoV-2 infection and the effect of nanoparticles on metabolite levels. It was clear that SARS-CoV-2 disrupted several pathways to ensure a sufficient supply of its building blocks to facilitate its replication. Such information can help in developing treatment strategies against viral infections and COVID-19 based on interventions that overcome these metabolic changes. Furthermore, it showed that even drug-free nanoparticles can exert an influence on biological systems as evidenced by metabolomics. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2023-08-16 2023 /pmc/articles/PMC10539420/ /pubmed/37587394 http://dx.doi.org/10.1007/s43440-023-00517-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
El-Derany, Marwa O.
Hanna, Diana M. F.
Youshia, John
Elmowafy, Enas
Farag, Mohamed A.
Azab, Samar S.
Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
title Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
title_full Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
title_fullStr Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
title_full_unstemmed Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
title_short Metabolomics-directed nanotechnology in viral diseases management: COVID-19 a case study
title_sort metabolomics-directed nanotechnology in viral diseases management: covid-19 a case study
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539420/
https://www.ncbi.nlm.nih.gov/pubmed/37587394
http://dx.doi.org/10.1007/s43440-023-00517-w
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