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Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis

Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions in diverse portions of the body. The treatment of AD is exclusively focused to limit the itching, reduce inflammation, and repair the breached barrier...

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Detalles Bibliográficos
Autores principales: Kakkar, Vandita, Saini, Komal, Singh, Kamalinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539427/
https://www.ncbi.nlm.nih.gov/pubmed/37668937
http://dx.doi.org/10.1007/s43440-023-00510-3
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author Kakkar, Vandita
Saini, Komal
Singh, Kamalinder K.
author_facet Kakkar, Vandita
Saini, Komal
Singh, Kamalinder K.
author_sort Kakkar, Vandita
collection PubMed
description Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions in diverse portions of the body. The treatment of AD is exclusively focused to limit the itching, reduce inflammation, and repair the breached barrier of the skin. Several therapeutic agents for the treatment and management of AD have been reported and are in use in clinics. However, the topical treatment of AD has been an unswerving challenge for the medical fraternity owing to the impaired skin barrier function in this chronic skin condition. To surmount the problems of conventional drug delivery systems, numerous nanotechnology-based formulations are emerging as alternative new modalities for AD. Latter enhances the bioavailability and delivery to the target disease site, improves drug permeation and therapeutic efficacy with reduced systemic and off-target side effects, and thus improves patient health and promotes compliance. This review aims to describe the various pathophysiological events involved in the occurrence of AD, current challenges in treatment, evidence of molecular markers of AD and its management, combinatorial treatment options, and the intervention of nanotechnology-based formulations for AD therapeutics. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-105394272023-09-30 Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis Kakkar, Vandita Saini, Komal Singh, Kamalinder K. Pharmacol Rep Review Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions in diverse portions of the body. The treatment of AD is exclusively focused to limit the itching, reduce inflammation, and repair the breached barrier of the skin. Several therapeutic agents for the treatment and management of AD have been reported and are in use in clinics. However, the topical treatment of AD has been an unswerving challenge for the medical fraternity owing to the impaired skin barrier function in this chronic skin condition. To surmount the problems of conventional drug delivery systems, numerous nanotechnology-based formulations are emerging as alternative new modalities for AD. Latter enhances the bioavailability and delivery to the target disease site, improves drug permeation and therapeutic efficacy with reduced systemic and off-target side effects, and thus improves patient health and promotes compliance. This review aims to describe the various pathophysiological events involved in the occurrence of AD, current challenges in treatment, evidence of molecular markers of AD and its management, combinatorial treatment options, and the intervention of nanotechnology-based formulations for AD therapeutics. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2023-09-05 2023 /pmc/articles/PMC10539427/ /pubmed/37668937 http://dx.doi.org/10.1007/s43440-023-00510-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kakkar, Vandita
Saini, Komal
Singh, Kamalinder K.
Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
title Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
title_full Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
title_fullStr Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
title_full_unstemmed Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
title_short Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
title_sort challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539427/
https://www.ncbi.nlm.nih.gov/pubmed/37668937
http://dx.doi.org/10.1007/s43440-023-00510-3
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