Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

Disruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota...

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Autores principales: Joshi, Mahika, Hiremath, Priyanka, John, Jeena, Ranadive, Niraja, Nandakumar, Krishnadas, Mudgal, Jayesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539462/
https://www.ncbi.nlm.nih.gov/pubmed/37673852
http://dx.doi.org/10.1007/s43440-023-00520-1
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author Joshi, Mahika
Hiremath, Priyanka
John, Jeena
Ranadive, Niraja
Nandakumar, Krishnadas
Mudgal, Jayesh
author_facet Joshi, Mahika
Hiremath, Priyanka
John, Jeena
Ranadive, Niraja
Nandakumar, Krishnadas
Mudgal, Jayesh
author_sort Joshi, Mahika
collection PubMed
description Disruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and anti-microbial effects. The immunomodulatory action of vitamins can halt the progression of skin diseases, and thus, understanding the immuno-pharmacology of these vitamins, especially for skin diseases can pave the way for their therapeutic potential. At the same time, molecular and cellular markers modulated with these vitamins and their derivatives need to be explored. The present review is focused on significant vitamins (vitamins A, B3, C, D, and E) consumed as nutritional supplements to discuss the outcomes and scope of studies related to skin immunity, health, and diseases. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-105394622023-09-30 Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases Joshi, Mahika Hiremath, Priyanka John, Jeena Ranadive, Niraja Nandakumar, Krishnadas Mudgal, Jayesh Pharmacol Rep Review Disruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and anti-microbial effects. The immunomodulatory action of vitamins can halt the progression of skin diseases, and thus, understanding the immuno-pharmacology of these vitamins, especially for skin diseases can pave the way for their therapeutic potential. At the same time, molecular and cellular markers modulated with these vitamins and their derivatives need to be explored. The present review is focused on significant vitamins (vitamins A, B3, C, D, and E) consumed as nutritional supplements to discuss the outcomes and scope of studies related to skin immunity, health, and diseases. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2023-09-06 2023 /pmc/articles/PMC10539462/ /pubmed/37673852 http://dx.doi.org/10.1007/s43440-023-00520-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Joshi, Mahika
Hiremath, Priyanka
John, Jeena
Ranadive, Niraja
Nandakumar, Krishnadas
Mudgal, Jayesh
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
title Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
title_full Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
title_fullStr Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
title_full_unstemmed Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
title_short Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
title_sort modulatory role of vitamins a, b3, c, d, and e on skin health, immunity, microbiome, and diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539462/
https://www.ncbi.nlm.nih.gov/pubmed/37673852
http://dx.doi.org/10.1007/s43440-023-00520-1
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