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Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy

Background: Intravesical prostatic protrusion (IPP) is common in prostate-related diseases, whose clinical significance in radical prostatectomy was unknown. Methods: 791 patients underwent robot-assisted or open radical prostatectomy at our institution were enrolled. The transabdominal ultrasound e...

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Autores principales: Tang, Jie, Xi, Wei, Zhu, Yanjun, Wang, Hang, Sun, Li'an, Jiang, Shuai, Guo, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539561/
https://www.ncbi.nlm.nih.gov/pubmed/37781077
http://dx.doi.org/10.7150/jca.86582
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author Tang, Jie
Xi, Wei
Zhu, Yanjun
Wang, Hang
Sun, Li'an
Jiang, Shuai
Guo, Jianming
author_facet Tang, Jie
Xi, Wei
Zhu, Yanjun
Wang, Hang
Sun, Li'an
Jiang, Shuai
Guo, Jianming
author_sort Tang, Jie
collection PubMed
description Background: Intravesical prostatic protrusion (IPP) is common in prostate-related diseases, whose clinical significance in radical prostatectomy was unknown. Methods: 791 patients underwent robot-assisted or open radical prostatectomy at our institution were enrolled. The transabdominal ultrasound examination of prostate and IPP was carried out preoperatively, by which IPP was classified as no (0-0.5cm, grade 0), slight (0.6-1.0cm, grade 1) and noticeable (>1.0cm, grade 2). Results: 185 (23.4%), 170 (21.5%) and 436 (55.1%) patients had no, slight and noticeable IPP, respectively. Generally, prostate specific antigen (PSA), Gleason score and pT stage increased with IPP grade. In particular, cases with grade 0 IPP had a decreased proportion of seminal vesicles' involvement than those with grade 1 and grade 2 IPP (p=0.035). Reconstruction of the bladder neck (in robot-assisted group), increased surgical bleeding (>200ml), and prolonged postoperative hospital stays (>14 days) happened more in patients with grade 2 IPP. Blood transfusion only happened in patients with noticeable IPP. PSM of bladder neck was only associated with higher IPP grade in open surgery group (p=0.032), not in robot-assisted surgery group. Conclusion: IPP is associated with cancer aggressiveness, surgery difficulty and PSM of bladder neck in prostate cancer. Assessment of it provides more information for operations.
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spelling pubmed-105395612023-09-30 Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy Tang, Jie Xi, Wei Zhu, Yanjun Wang, Hang Sun, Li'an Jiang, Shuai Guo, Jianming J Cancer Research Paper Background: Intravesical prostatic protrusion (IPP) is common in prostate-related diseases, whose clinical significance in radical prostatectomy was unknown. Methods: 791 patients underwent robot-assisted or open radical prostatectomy at our institution were enrolled. The transabdominal ultrasound examination of prostate and IPP was carried out preoperatively, by which IPP was classified as no (0-0.5cm, grade 0), slight (0.6-1.0cm, grade 1) and noticeable (>1.0cm, grade 2). Results: 185 (23.4%), 170 (21.5%) and 436 (55.1%) patients had no, slight and noticeable IPP, respectively. Generally, prostate specific antigen (PSA), Gleason score and pT stage increased with IPP grade. In particular, cases with grade 0 IPP had a decreased proportion of seminal vesicles' involvement than those with grade 1 and grade 2 IPP (p=0.035). Reconstruction of the bladder neck (in robot-assisted group), increased surgical bleeding (>200ml), and prolonged postoperative hospital stays (>14 days) happened more in patients with grade 2 IPP. Blood transfusion only happened in patients with noticeable IPP. PSM of bladder neck was only associated with higher IPP grade in open surgery group (p=0.032), not in robot-assisted surgery group. Conclusion: IPP is associated with cancer aggressiveness, surgery difficulty and PSM of bladder neck in prostate cancer. Assessment of it provides more information for operations. Ivyspring International Publisher 2023-09-11 /pmc/articles/PMC10539561/ /pubmed/37781077 http://dx.doi.org/10.7150/jca.86582 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Tang, Jie
Xi, Wei
Zhu, Yanjun
Wang, Hang
Sun, Li'an
Jiang, Shuai
Guo, Jianming
Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy
title Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy
title_full Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy
title_fullStr Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy
title_full_unstemmed Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy
title_short Clinical Significance of Preoperative Assessment of Intravesical Prostatic Protrusion in Radical Prostatectomy
title_sort clinical significance of preoperative assessment of intravesical prostatic protrusion in radical prostatectomy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539561/
https://www.ncbi.nlm.nih.gov/pubmed/37781077
http://dx.doi.org/10.7150/jca.86582
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