The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors

The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gas...

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Autores principales: Kong, Minyu, Yu, Xiao, Guo, Wenzhi, Guo, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539694/
https://www.ncbi.nlm.nih.gov/pubmed/37781524
http://dx.doi.org/10.7150/ijbs.87028
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author Kong, Minyu
Yu, Xiao
Guo, Wenzhi
Guo, Ran
author_facet Kong, Minyu
Yu, Xiao
Guo, Wenzhi
Guo, Ran
author_sort Kong, Minyu
collection PubMed
description The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gastric, colorectal, liver, and pancreatic cancers). Therefore, we summarize the interrelation process between ncRNAs and methylation modifications in GI tumors, including the detailed mechanism of methylation enzyme regulation of ncRNAs, the molecular mechanism of ncRNAs regulation of methylation modifications, and the correlation between the interactions between ncRNAs and methylation modifications and clinical features of tumors. Finally, we discuss the potential value of ncRNAs and methylation modifications in clinical diagnosis and therapy.
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spelling pubmed-105396942023-09-30 The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors Kong, Minyu Yu, Xiao Guo, Wenzhi Guo, Ran Int J Biol Sci Review The aberrant expression of methylation and ncRNAs, two crucial regulators of epigenetic modifications, has been widely demonstrated in cancer. The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gastric, colorectal, liver, and pancreatic cancers). Therefore, we summarize the interrelation process between ncRNAs and methylation modifications in GI tumors, including the detailed mechanism of methylation enzyme regulation of ncRNAs, the molecular mechanism of ncRNAs regulation of methylation modifications, and the correlation between the interactions between ncRNAs and methylation modifications and clinical features of tumors. Finally, we discuss the potential value of ncRNAs and methylation modifications in clinical diagnosis and therapy. Ivyspring International Publisher 2023-09-11 /pmc/articles/PMC10539694/ /pubmed/37781524 http://dx.doi.org/10.7150/ijbs.87028 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Kong, Minyu
Yu, Xiao
Guo, Wenzhi
Guo, Ran
The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
title The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
title_full The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
title_fullStr The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
title_full_unstemmed The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
title_short The bidirectional interplay between ncRNAs and methylation modifications in gastrointestinal tumors
title_sort bidirectional interplay between ncrnas and methylation modifications in gastrointestinal tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539694/
https://www.ncbi.nlm.nih.gov/pubmed/37781524
http://dx.doi.org/10.7150/ijbs.87028
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