Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing

Diabetic wounds are characterized by delayed and incomplete healing. As one of the most common complications of diabetes, diabetic wounds can be fatal in some cases. Programmed cell death (PCD) is an active and ordered cell death mode determined by genes, including apoptosis, autophagy, pyroptosis,...

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Detalles Bibliográficos
Autores principales: Song, Jingyu, Zhu, Keyu, Wang, Haiping, Wu, Min, Wu, Yiping, Zhang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539695/
https://www.ncbi.nlm.nih.gov/pubmed/37781514
http://dx.doi.org/10.7150/ijbs.88461
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author Song, Jingyu
Zhu, Keyu
Wang, Haiping
Wu, Min
Wu, Yiping
Zhang, Qi
author_facet Song, Jingyu
Zhu, Keyu
Wang, Haiping
Wu, Min
Wu, Yiping
Zhang, Qi
author_sort Song, Jingyu
collection PubMed
description Diabetic wounds are characterized by delayed and incomplete healing. As one of the most common complications of diabetes, diabetic wounds can be fatal in some cases. Programmed cell death (PCD) is an active and ordered cell death mode determined by genes, including apoptosis, autophagy, pyroptosis, necroptosis, ferroptosis, and cuproptosis. It is currently believed that PCD plays a crucial role in diabetic wound healing. Diabetic hyperglycemic environments can lead to abnormal PCD in various cells during healing processes, thereby affecting the activity and function of cells and interfering with diabetic wound healing. Therefore, this review focuses on the new roles and mechanisms of PCD in diabetic wound healing. Moreover, the challenges and perspectives related to PCD in diabetic wound healing are presented, which will bring new insights to improve diabetic wound healing.
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spelling pubmed-105396952023-09-30 Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing Song, Jingyu Zhu, Keyu Wang, Haiping Wu, Min Wu, Yiping Zhang, Qi Int J Biol Sci Review Diabetic wounds are characterized by delayed and incomplete healing. As one of the most common complications of diabetes, diabetic wounds can be fatal in some cases. Programmed cell death (PCD) is an active and ordered cell death mode determined by genes, including apoptosis, autophagy, pyroptosis, necroptosis, ferroptosis, and cuproptosis. It is currently believed that PCD plays a crucial role in diabetic wound healing. Diabetic hyperglycemic environments can lead to abnormal PCD in various cells during healing processes, thereby affecting the activity and function of cells and interfering with diabetic wound healing. Therefore, this review focuses on the new roles and mechanisms of PCD in diabetic wound healing. Moreover, the challenges and perspectives related to PCD in diabetic wound healing are presented, which will bring new insights to improve diabetic wound healing. Ivyspring International Publisher 2023-09-18 /pmc/articles/PMC10539695/ /pubmed/37781514 http://dx.doi.org/10.7150/ijbs.88461 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Song, Jingyu
Zhu, Keyu
Wang, Haiping
Wu, Min
Wu, Yiping
Zhang, Qi
Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing
title Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing
title_full Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing
title_fullStr Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing
title_full_unstemmed Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing
title_short Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing
title_sort deciphering the emerging role of programmed cell death in diabetic wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539695/
https://www.ncbi.nlm.nih.gov/pubmed/37781514
http://dx.doi.org/10.7150/ijbs.88461
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