Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway

Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). However, the process by which hypoxia promotes the formation of a pre-metastatic niche (PMN) and its underlying mechanism remain unclear. Methods: Exosomes derived from normoxic and hypoxic HCC cell...

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Detalles Bibliográficos
Autores principales: Jia, Wentao, Liang, Shufang, Lin, Wanfu, Li, Shu, Yuan, Jiaying, Jin, Mingming, Nie, Shuchang, Zhang, Ya'ni, Zhai, Xiaofeng, Zhou, Liping, Ling, Changquan, Cheng, Binbin, Ling, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539707/
https://www.ncbi.nlm.nih.gov/pubmed/37781522
http://dx.doi.org/10.7150/ijbs.86767

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