Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator

The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen ( [Formula: see text] H [Formula: see text] -b...

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Detalles Bibliográficos
Autores principales: Ellermann, Frowin, Pravdivtsev, Andrey, Hövener, Jan-Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539807/
https://www.ncbi.nlm.nih.gov/pubmed/37904754
http://dx.doi.org/10.5194/mr-2-49-2021
Descripción
Sumario:The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen ( [Formula: see text] H [Formula: see text] -based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a [Formula: see text] H [Formula: see text] generator is necessary. Available commercial [Formula: see text] H [Formula: see text] generators are relatively expensive (EUR 10 000–150 000). To facilitate the spread of [Formula: see text] H [Formula: see text] -based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR  [Formula: see text] ) 50-bar liquid-nitrogen-cooled [Formula: see text] H [Formula: see text] generator.

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