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Toceranib phosphate and firocoxib-mediated partial response in a dog with advanced intranasal sarcoma

A nine-year-old, castrated male mixed-breed dog presented with a three-month history of sneezing and stertorous breathing. Computed tomography revealed a soft tissue mass in the left nasal cavity with lysis of the cribriform plate. The mass was diagnosed as intranasal sarcoma based on histopathologi...

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Detalles Bibliográficos
Autores principales: OSADA, Hironari, OKAZAWA, Taiga, KUSHIDA, Kazuya, KISHIMOTO, Miori, IKEDA, Mitsuhiro, KONDO, Hirotaka, KIMURA, Junpei, OHMORI, Keitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539811/
https://www.ncbi.nlm.nih.gov/pubmed/37532540
http://dx.doi.org/10.1292/jvms.22-0542
Descripción
Sumario:A nine-year-old, castrated male mixed-breed dog presented with a three-month history of sneezing and stertorous breathing. Computed tomography revealed a soft tissue mass in the left nasal cavity with lysis of the cribriform plate. The mass was diagnosed as intranasal sarcoma based on histopathological analysis. The tumor cells were immunohistochemically positive for KIT and platelet-derived growth factor receptor α/β and negative for vascular endothelial growth factor receptor 2 and cyclooxygenase-2. Treatment with toceranib phosphate (TOC) and firocoxib reduced the tumor size, which was defined as partial response (PR). After PR induction, TOC alone mediated survival for 205 days. This case report suggests that the combination of TOC and possibly firocoxib may be a therapeutic option for canine intranasal sarcoma.