Pleural mesothelioma in a California sea lion (Zalophus californianus)

A 25-year-old female California sea lion (Zalophus californianus) reared in an aquarium died following a history of anorexia, lethargy, abnormal protrusion of the skin, and oral respiration. At necropsy, multiple yellowish-white nodules with diameters of 0.1–0.5 cm were disseminated in the thoracic...

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Detalles Bibliográficos
Autores principales: TAKAMI, Yuki, TANAKA, Miyuu, MORITA, Masahiro, MARUNO, Takaya, ANAI, Naohiro, SUDO, Tsubasa, KEZUKA, Chiho, IZAWA, Takeshi, YAMATE, Jyoji, KUWAMURA, Mitsuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2023
Materias:
Wildlife Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539812/
https://www.ncbi.nlm.nih.gov/pubmed/37532588
http://dx.doi.org/10.1292/jvms.22-0457
Descripción
Sumario:A 25-year-old female California sea lion (Zalophus californianus) reared in an aquarium died following a history of anorexia, lethargy, abnormal protrusion of the skin, and oral respiration. At necropsy, multiple yellowish-white nodules with diameters of 0.1–0.5 cm were disseminated in the thoracic cavity and lungs. Histopathologically, the nodules were continuous with normal mesothelium and were characterized by the proliferation of spindle-shaped to polygonal neoplastic cells with prominent atypia. The neoplastic cells exhibited diffuse, strong staining for vimentin and partial, weak to moderate staining for cytokeratin AE1/AE3. Based on these findings, the lesions were diagnosed as pleural mesothelioma. This study reports the first case of pleural mesothelioma in California sea lion.

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