miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8(+) T cell infiltration

Immunotherapies have emerged as promising strategies for cancer treatment. However, existing immunotherapies have poor activity in high-grade serous ovarian cancer (HGSC) due to the immunosuppressive tumor microenvironment and the associated low tumoral CD8(+) T cell (CTL) infiltration. Through mult...

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Detalles Bibliográficos
Autores principales: Chen, Rui, Coleborn, Elaina, Bhavsar, Chintan, Wang, Yue, Alim, Louisa, Wilkinson, Andrew N., Tran, Michelle A., Irgam, Gowri, Atluri, Sharat, Wong, Kiefer, Shim, Jae-Jun, Adityan, Siddharth, Lee, Ju-Seog, Overwijk, Willem W., Steptoe, Raymond, Yang, Da, Wu, Sherry Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539880/
https://www.ncbi.nlm.nih.gov/pubmed/37781339
http://dx.doi.org/10.1016/j.omto.2023.09.001

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