DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling

The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING (Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or damage. In cancer cells, this pathway can be activated through persistent DNA damage and chromosomal instability, which results...

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Detalles Bibliográficos
Autores principales: Wheeler, Otto P.G., Unterholzner, Leonie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539950/
https://www.ncbi.nlm.nih.gov/pubmed/37534795
http://dx.doi.org/10.1042/EBC20220241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539950/
https://www.ncbi.nlm.nih.gov/pubmed/37534795
http://dx.doi.org/10.1042/EBC20220241

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