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DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling
The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING (Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or damage. In cancer cells, this pathway can be activated through persistent DNA damage and chromosomal instability, which results...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Portland Press Ltd.
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539950/ https://www.ncbi.nlm.nih.gov/pubmed/37534795 http://dx.doi.org/10.1042/EBC20220241 |