Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish

Pharmacological inhibition of mitochondrial fatty acid oxidation (FAO) has been clinically used to alleviate certain metabolic diseases by remodeling cellular metabolism. However, mitochondrial FAO inhibition also leads to mechanistic target of rapamycin complex 1 (mTORC1) activation–related protein...

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Detalles Bibliográficos
Autores principales: Zhou, Wen-Hao, Luo, Yuan, Li, Rui-Xin, Degrace, Pascal, Jourdan, Tony, Qiao, Fang, Chen, Li-Qiao, Zhang, Mei-Ling, Du, Zhen-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540046/
https://www.ncbi.nlm.nih.gov/pubmed/37660921
http://dx.doi.org/10.1016/j.jbc.2023.105220

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