The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR(+) CD8(+) effector state, and its deletion improves checkpoint blockade

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CD8(+) T cell exhaustion (T(EX)) impairs the ability of T cells to clear chronic infection or cancer. While T(EX) are hypofunctional, some T(EX) retain effector gene signatures, a feature associated with killer lectin-like receptor (KLR) expression. Although KLR(+) T(EX) (T(KLR)) may improve control...

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Detalles Bibliográficos
Autores principales: McClory, Susan E., Bardhan, Oishi, Rome, Kelly S., Giles, Josephine R., Baxter, Amy E., Xu, Lanwei, Gimotty, Phyllis A., Faryabi, Robert B., John Wherry, E., Pear, Warren S., Jordan, Martha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540077/
https://www.ncbi.nlm.nih.gov/pubmed/37527035
http://dx.doi.org/10.1016/j.celrep.2023.112905
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