Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report

The association between primary immunodeficiencies and autoinflammatory disorders has been popularized over the past decade. In this report, we illustrated the co-infection of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in a three-year-old Jordanian male patient with an extremely rare variant...

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Autores principales: Al Zu’bi, Yazan O, Al Sharie, Ahmed H, Al-Sweedan, Suleimman, Al-Khatib, Sohaib, Jaradat, Saied A, Al Tamimi, Eyad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540091/
https://www.ncbi.nlm.nih.gov/pubmed/37779769
http://dx.doi.org/10.7759/cureus.44360
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author Al Zu’bi, Yazan O
Al Sharie, Ahmed H
Al-Sweedan, Suleimman
Al-Khatib, Sohaib
Jaradat, Saied A
Al Tamimi, Eyad
author_facet Al Zu’bi, Yazan O
Al Sharie, Ahmed H
Al-Sweedan, Suleimman
Al-Khatib, Sohaib
Jaradat, Saied A
Al Tamimi, Eyad
author_sort Al Zu’bi, Yazan O
collection PubMed
description The association between primary immunodeficiencies and autoinflammatory disorders has been popularized over the past decade. In this report, we illustrated the co-infection of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in a three-year-old Jordanian male patient with an extremely rare variant of the CYBB gene (c.125C>G, p.Thr42Arg) associated with chronic granulomatous disease (CGD) coexisting with familial Mediterranean fever (FMF). CGD and FMF co-existence induced early-onset inflammatory bowel disease mainly resembling Crohn’s disease.
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spelling pubmed-105400912023-09-30 Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report Al Zu’bi, Yazan O Al Sharie, Ahmed H Al-Sweedan, Suleimman Al-Khatib, Sohaib Jaradat, Saied A Al Tamimi, Eyad Cureus Pathology The association between primary immunodeficiencies and autoinflammatory disorders has been popularized over the past decade. In this report, we illustrated the co-infection of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in a three-year-old Jordanian male patient with an extremely rare variant of the CYBB gene (c.125C>G, p.Thr42Arg) associated with chronic granulomatous disease (CGD) coexisting with familial Mediterranean fever (FMF). CGD and FMF co-existence induced early-onset inflammatory bowel disease mainly resembling Crohn’s disease. Cureus 2023-08-30 /pmc/articles/PMC10540091/ /pubmed/37779769 http://dx.doi.org/10.7759/cureus.44360 Text en Copyright © 2023, Al Zu’bi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Al Zu’bi, Yazan O
Al Sharie, Ahmed H
Al-Sweedan, Suleimman
Al-Khatib, Sohaib
Jaradat, Saied A
Al Tamimi, Eyad
Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report
title Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report
title_full Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report
title_fullStr Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report
title_full_unstemmed Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report
title_short Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report
title_sort cytomegalovirus and epstein-barr virus co-infection in a patient with chronic granulomatous disease co-existing with familial mediterranean fever and early-onset inflammatory bowel disease: a case report
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540091/
https://www.ncbi.nlm.nih.gov/pubmed/37779769
http://dx.doi.org/10.7759/cureus.44360
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