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Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients
BACKGROUND: Pulmonary thromboembolism (PTE) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which raises the COVID‐19 disease's fatality rate from 3% to 45%. Nevertheless, due to fairly indistinguishable clinical symptoms and a lack of validated clinica...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540144/ https://www.ncbi.nlm.nih.gov/pubmed/37773719 http://dx.doi.org/10.1002/iid3.1012 |
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author | Radkhah, Hanieh Mansouri, Ensieh Sadat Rahimipour Anaraki, Shiva Gholizadeh Mesgarha, Milad Sheikhy, Ali Khadembashiri, Mohamad Mehdi Khadembashiri, Mohamad Amin Eslami, Mohamad Mahmoodi, Tara Inanloo, Behnaz Pour Mohammad, Arash |
author_facet | Radkhah, Hanieh Mansouri, Ensieh Sadat Rahimipour Anaraki, Shiva Gholizadeh Mesgarha, Milad Sheikhy, Ali Khadembashiri, Mohamad Mehdi Khadembashiri, Mohamad Amin Eslami, Mohamad Mahmoodi, Tara Inanloo, Behnaz Pour Mohammad, Arash |
author_sort | Radkhah, Hanieh |
collection | PubMed |
description | BACKGROUND: Pulmonary thromboembolism (PTE) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which raises the COVID‐19 disease's fatality rate from 3% to 45%. Nevertheless, due to fairly indistinguishable clinical symptoms and a lack of validated clinical prediction models, PTE diagnosis in COVID‐19 patients is challenging. This study aims to investigate the applicability of hematological indices to predict PTE incidence and its severity in SARS‐CoV‐2 patients. METHODS: A retrospective cohort study was conducted on hospitalized patients with a confirmed diagnosis of SARS‐CoV‐2 infection who underwent CT angiography to assess probable PTE in them. The correlation between complete blood count parameters 1 day before CT angiography and CT angiography outcomes, and simplified pulmonary embolism severity index (s‐PESI) was investigated. RESULTS: We discovered that among individuals with a probable PTE, males and those with higher platelet‐to‐lymphocyte (PLR) and neutrophil‐to‐lymphocyte (NLR) ratios had a greater likelihood of PTE incidence (p < .001, .027, and .037, respectively). PLR was a significant and independent predictor of PTE with a p value of .045. Moreover, a higher neutrophil count was associated with a higher s‐PESI score in COVID‐19 patients developing PTE (p: .038). CONCLUSIONS: Among hematological indices, NLR and more precisely PLR are cost‐effective and simply calculable markers that can assist physicians in determining whether or not COVID‐19 patients with clinically probable PTE require CT angiography and the higher neutrophil count can be employed as an indicator of PTE severity in COVID‐19 patients. Further large multicenter and prospective studies are warranted to corroborate these observations. |
format | Online Article Text |
id | pubmed-10540144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105401442023-09-30 Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients Radkhah, Hanieh Mansouri, Ensieh Sadat Rahimipour Anaraki, Shiva Gholizadeh Mesgarha, Milad Sheikhy, Ali Khadembashiri, Mohamad Mehdi Khadembashiri, Mohamad Amin Eslami, Mohamad Mahmoodi, Tara Inanloo, Behnaz Pour Mohammad, Arash Immun Inflamm Dis Original Articles BACKGROUND: Pulmonary thromboembolism (PTE) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which raises the COVID‐19 disease's fatality rate from 3% to 45%. Nevertheless, due to fairly indistinguishable clinical symptoms and a lack of validated clinical prediction models, PTE diagnosis in COVID‐19 patients is challenging. This study aims to investigate the applicability of hematological indices to predict PTE incidence and its severity in SARS‐CoV‐2 patients. METHODS: A retrospective cohort study was conducted on hospitalized patients with a confirmed diagnosis of SARS‐CoV‐2 infection who underwent CT angiography to assess probable PTE in them. The correlation between complete blood count parameters 1 day before CT angiography and CT angiography outcomes, and simplified pulmonary embolism severity index (s‐PESI) was investigated. RESULTS: We discovered that among individuals with a probable PTE, males and those with higher platelet‐to‐lymphocyte (PLR) and neutrophil‐to‐lymphocyte (NLR) ratios had a greater likelihood of PTE incidence (p < .001, .027, and .037, respectively). PLR was a significant and independent predictor of PTE with a p value of .045. Moreover, a higher neutrophil count was associated with a higher s‐PESI score in COVID‐19 patients developing PTE (p: .038). CONCLUSIONS: Among hematological indices, NLR and more precisely PLR are cost‐effective and simply calculable markers that can assist physicians in determining whether or not COVID‐19 patients with clinically probable PTE require CT angiography and the higher neutrophil count can be employed as an indicator of PTE severity in COVID‐19 patients. Further large multicenter and prospective studies are warranted to corroborate these observations. John Wiley and Sons Inc. 2023-09-29 /pmc/articles/PMC10540144/ /pubmed/37773719 http://dx.doi.org/10.1002/iid3.1012 Text en © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Radkhah, Hanieh Mansouri, Ensieh Sadat Rahimipour Anaraki, Shiva Gholizadeh Mesgarha, Milad Sheikhy, Ali Khadembashiri, Mohamad Mehdi Khadembashiri, Mohamad Amin Eslami, Mohamad Mahmoodi, Tara Inanloo, Behnaz Pour Mohammad, Arash Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients |
title | Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients |
title_full | Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients |
title_fullStr | Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients |
title_full_unstemmed | Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients |
title_short | Predictive value of hematological indices on incidence and severity of pulmonary embolism in COVID‐19 patients |
title_sort | predictive value of hematological indices on incidence and severity of pulmonary embolism in covid‐19 patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540144/ https://www.ncbi.nlm.nih.gov/pubmed/37773719 http://dx.doi.org/10.1002/iid3.1012 |
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