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Recording Binding Information Directly into DNA-Encoded Libraries Using Terminal Deoxynucleotidyl Transferase

[Image: see text] Terminal deoxynucleotidyl transferase (TdT) is an unusual DNA polymerase that adds untemplated dNTPs to 3′-ends of DNA. If a target protein is expressed as a TdT fusion and incubated with a DNA-encoded library (DEL) in the presence of dATP, the binders of the target induce proximit...

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Detalles Bibliográficos
Autores principales:	Schneider, Lukas A., Sauter, Basilius, Dagher, Koder, Gillingham, Dennis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540198/ https://www.ncbi.nlm.nih.gov/pubmed/37704585 http://dx.doi.org/10.1021/jacs.3c05961

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