Multivalent Dynamic Colocalization of Avian Influenza Polymerase and Nucleoprotein by Intrinsically Disordered ANP32A Reveals the Molecular Basis of Human Adaptation

[Image: see text] Adaptation of avian influenza RNA polymerase (FluPol) to human cells requires mutations on the 627-NLS domains of the PB2 subunit. The E627K adaptive mutation compensates a 33-amino-acid deletion in the acidic intrinsically disordered domain of the host transcription regulator ANP3...

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Detalles Bibliográficos
Autores principales: Camacho-Zarco, Aldo R., Yu, Lefan, Krischuns, Tim, Dedeoglu, Selin, Maurin, Damien, Bouvignies, Guillaume, Crépin, Thibaut, Ruigrok, Rob W. H., Cusack, Stephan, Naffakh, Nadia, Blackledge, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540212/
https://www.ncbi.nlm.nih.gov/pubmed/37707433
http://dx.doi.org/10.1021/jacs.3c06965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540212/
https://www.ncbi.nlm.nih.gov/pubmed/37707433
http://dx.doi.org/10.1021/jacs.3c06965

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