Cargando…
Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective
INTRODUCTION: Studies showing associations between inflammation in suicide are typically cross-sectional. Present study investigated how cytokine levels track with suicidal ideation and severity longitudinally. METHODS: Veterans with a diagnosis of major depressive disorder (MDD) with or without sui...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540304/ https://www.ncbi.nlm.nih.gov/pubmed/37779624 http://dx.doi.org/10.3389/fpsyt.2023.1231031 |
_version_ | 1785113685518188544 |
---|---|
author | Sun, Shengnan Wilson, Caroline M. Alter, Sharon Ge, Yongchao Hazlett, Erin A. Goodman, Marianne Yehuda, Rachel Galfalvy, Hanga Haghighi, Fatemeh |
author_facet | Sun, Shengnan Wilson, Caroline M. Alter, Sharon Ge, Yongchao Hazlett, Erin A. Goodman, Marianne Yehuda, Rachel Galfalvy, Hanga Haghighi, Fatemeh |
author_sort | Sun, Shengnan |
collection | PubMed |
description | INTRODUCTION: Studies showing associations between inflammation in suicide are typically cross-sectional. Present study investigated how cytokine levels track with suicidal ideation and severity longitudinally. METHODS: Veterans with a diagnosis of major depressive disorder (MDD) with or without suicide attempt history (MDD/SA n = 38, MDD/NS n = 41) and non-psychiatric non-attempter controls (HC n = 33) were recruited, MDD/SA and HC groups were followed longitudinally at 3 months and 6 months. Blood plasma was collected and processed using Luminex Immunology Multiplex technology. RESULTS: Significant differences in depression severity (BDI) and suicidal ideation severity (SSI) were observed across all groups at study entry, wherein MDD/SA group had the highest scores followed by MDD/NS and HC, respectively. Cytokines IL-1β, IL-4, TNF-α, IFN-γ, and IL-6 were examined at study entry and longitudinally, with IL6 levels differing significantly across the groups (p = 0.0123) at study entry. Significant differences in changes in cytokine levels between depressed attempters and the control group were detected for IL-6 (interaction F(1,91.77) = 5.58, p = 0.0203) and TNF-α (F(1,101.73) = 4.69, p = 0.0327). However, only depressed attempters showed a significant change, in IL-6 and TNF-α levels, decreasing over time [IL-6: b = −0.04, 95% CI = (−0.08, −0.01), p = 0.0245 and TNF-α: b = −0.02, 95% CI = (−0.04, −0.01), p = 0.0196]. Although IL-6 levels were not predictive of suicidal ideation presence [OR = 1.34, 95% CI = (0.77, 2.33), p = 0.3067], IL-6 levels were significantly associated with suicidal ideation severity (b = 0.19, p = 0.0422). DISCUSSION: IL-6 was not associated with presence of suicidal ideation. IL-6 however, was associated with severity of ideation, suggesting that IL-6 may be useful in clinical practice, as an objective marker of heightened suicide risk. |
format | Online Article Text |
id | pubmed-10540304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105403042023-09-30 Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective Sun, Shengnan Wilson, Caroline M. Alter, Sharon Ge, Yongchao Hazlett, Erin A. Goodman, Marianne Yehuda, Rachel Galfalvy, Hanga Haghighi, Fatemeh Front Psychiatry Psychiatry INTRODUCTION: Studies showing associations between inflammation in suicide are typically cross-sectional. Present study investigated how cytokine levels track with suicidal ideation and severity longitudinally. METHODS: Veterans with a diagnosis of major depressive disorder (MDD) with or without suicide attempt history (MDD/SA n = 38, MDD/NS n = 41) and non-psychiatric non-attempter controls (HC n = 33) were recruited, MDD/SA and HC groups were followed longitudinally at 3 months and 6 months. Blood plasma was collected and processed using Luminex Immunology Multiplex technology. RESULTS: Significant differences in depression severity (BDI) and suicidal ideation severity (SSI) were observed across all groups at study entry, wherein MDD/SA group had the highest scores followed by MDD/NS and HC, respectively. Cytokines IL-1β, IL-4, TNF-α, IFN-γ, and IL-6 were examined at study entry and longitudinally, with IL6 levels differing significantly across the groups (p = 0.0123) at study entry. Significant differences in changes in cytokine levels between depressed attempters and the control group were detected for IL-6 (interaction F(1,91.77) = 5.58, p = 0.0203) and TNF-α (F(1,101.73) = 4.69, p = 0.0327). However, only depressed attempters showed a significant change, in IL-6 and TNF-α levels, decreasing over time [IL-6: b = −0.04, 95% CI = (−0.08, −0.01), p = 0.0245 and TNF-α: b = −0.02, 95% CI = (−0.04, −0.01), p = 0.0196]. Although IL-6 levels were not predictive of suicidal ideation presence [OR = 1.34, 95% CI = (0.77, 2.33), p = 0.3067], IL-6 levels were significantly associated with suicidal ideation severity (b = 0.19, p = 0.0422). DISCUSSION: IL-6 was not associated with presence of suicidal ideation. IL-6 however, was associated with severity of ideation, suggesting that IL-6 may be useful in clinical practice, as an objective marker of heightened suicide risk. Frontiers Media S.A. 2023-09-15 /pmc/articles/PMC10540304/ /pubmed/37779624 http://dx.doi.org/10.3389/fpsyt.2023.1231031 Text en Copyright © 2023 Sun, Wilson, Alter, Ge, Hazlett, Goodman, Yehuda, Galfalvy and Haghighi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Sun, Shengnan Wilson, Caroline M. Alter, Sharon Ge, Yongchao Hazlett, Erin A. Goodman, Marianne Yehuda, Rachel Galfalvy, Hanga Haghighi, Fatemeh Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective |
title | Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective |
title_full | Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective |
title_fullStr | Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective |
title_full_unstemmed | Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective |
title_short | Association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective |
title_sort | association of interleukin-6 with suicidal ideation in veterans: a longitudinal perspective |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540304/ https://www.ncbi.nlm.nih.gov/pubmed/37779624 http://dx.doi.org/10.3389/fpsyt.2023.1231031 |
work_keys_str_mv | AT sunshengnan associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT wilsoncarolinem associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT altersharon associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT geyongchao associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT hazletterina associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT goodmanmarianne associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT yehudarachel associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT galfalvyhanga associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective AT haghighifatemeh associationofinterleukin6withsuicidalideationinveteransalongitudinalperspective |