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Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis

OBJECTIVE: Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA with risk of falls, recurrent falls, and fractures. METHODS: We conducted an ele...

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Autores principales: Zhang, Youyou, Li, Xiaoxi, Wang, Yining, Ge, Liru, Pan, Faming, Winzenberg, Tania, Cai, Guoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540335/
https://www.ncbi.nlm.nih.gov/pubmed/37770969
http://dx.doi.org/10.1186/s13075-023-03179-4
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author Zhang, Youyou
Li, Xiaoxi
Wang, Yining
Ge, Liru
Pan, Faming
Winzenberg, Tania
Cai, Guoqi
author_facet Zhang, Youyou
Li, Xiaoxi
Wang, Yining
Ge, Liru
Pan, Faming
Winzenberg, Tania
Cai, Guoqi
author_sort Zhang, Youyou
collection PubMed
description OBJECTIVE: Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA with risk of falls, recurrent falls, and fractures. METHODS: We conducted an electronic search of databases from inception to February 2023. Two authors independently screened studies, extracted data, and assessed the risk of bias using the Newcastle-Ottawa Scale tool in eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. RESULTS: Of 17 studies included (n = 862849), 2 had a high risk of bias. Among studies that evaluated falls or fractures as outcomes, 7/8 (87.5%) and 5/11 (45.5%) were self-reported, respectively. Both symptomatic knee and hip OA were associated with increased risk of recurrent falls (knee: OR = 1.55, 95% CI 1.10 to 2.18; hip: OR = 1.50, 95% CI 1.28 to 1.75) but not falls or fractures. Radiographic knee OA increased risk of falls (OR = 1.28, 95% CI 1.03 to 1.59) and did not significantly increase risk of recurrent falls (OR = 1.39, 95% CI 0.97 to 1.97) or fractures (OR = 1.22, 95% CI 0.99 to 1.52). Radiographic hip OA decreased the risk of recurrent falls (OR = 0.70, 95% CI 0.51 to 0.96) but had no statistically significant association with fractures (OR = 1.16, 95% CI 0.79 to 1.71). CONCLUSION: Symptomatic knee and hip OA were both associated with an increased risk of recurrent falls, and radiographic knee OA was associated with an increased risk of falls. No statistically significant associations of radiographic and symptomatic knee or hip OA with fractures were found. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-023-03179-4.
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spelling pubmed-105403352023-09-30 Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis Zhang, Youyou Li, Xiaoxi Wang, Yining Ge, Liru Pan, Faming Winzenberg, Tania Cai, Guoqi Arthritis Res Ther Research OBJECTIVE: Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA with risk of falls, recurrent falls, and fractures. METHODS: We conducted an electronic search of databases from inception to February 2023. Two authors independently screened studies, extracted data, and assessed the risk of bias using the Newcastle-Ottawa Scale tool in eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models. RESULTS: Of 17 studies included (n = 862849), 2 had a high risk of bias. Among studies that evaluated falls or fractures as outcomes, 7/8 (87.5%) and 5/11 (45.5%) were self-reported, respectively. Both symptomatic knee and hip OA were associated with increased risk of recurrent falls (knee: OR = 1.55, 95% CI 1.10 to 2.18; hip: OR = 1.50, 95% CI 1.28 to 1.75) but not falls or fractures. Radiographic knee OA increased risk of falls (OR = 1.28, 95% CI 1.03 to 1.59) and did not significantly increase risk of recurrent falls (OR = 1.39, 95% CI 0.97 to 1.97) or fractures (OR = 1.22, 95% CI 0.99 to 1.52). Radiographic hip OA decreased the risk of recurrent falls (OR = 0.70, 95% CI 0.51 to 0.96) but had no statistically significant association with fractures (OR = 1.16, 95% CI 0.79 to 1.71). CONCLUSION: Symptomatic knee and hip OA were both associated with an increased risk of recurrent falls, and radiographic knee OA was associated with an increased risk of falls. No statistically significant associations of radiographic and symptomatic knee or hip OA with fractures were found. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-023-03179-4. BioMed Central 2023-09-29 2023 /pmc/articles/PMC10540335/ /pubmed/37770969 http://dx.doi.org/10.1186/s13075-023-03179-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Youyou
Li, Xiaoxi
Wang, Yining
Ge, Liru
Pan, Faming
Winzenberg, Tania
Cai, Guoqi
Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
title Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
title_full Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
title_fullStr Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
title_full_unstemmed Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
title_short Association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
title_sort association of knee and hip osteoarthritis with the risk of falls and fractures: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540335/
https://www.ncbi.nlm.nih.gov/pubmed/37770969
http://dx.doi.org/10.1186/s13075-023-03179-4
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