Refactoring the architecture of a polyketide gene cluster enhances docosahexaenoic acid production in Yarrowia lipolytica through improved expression and genetic stability

BACKGROUND: Long-chain polyunsaturated fatty acids (LC-PUFAs), such as docosahexaenoic acid (DHA), are essential for human health and have been widely used in the food and pharmaceutical industries. However, the limited availability of natural sources, such as oily fish, has led to the pursuit of mi...

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Detalles Bibliográficos
Autores principales: Dietrich, Demian, Jovanovic-Gasovic, Sofija, Cao, Peng, Kohlstedt, Michael, Wittmann, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540379/
https://www.ncbi.nlm.nih.gov/pubmed/37773137
http://dx.doi.org/10.1186/s12934-023-02209-9

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