Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route t...

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Autores principales: Mitermite, Morgane, Elizari, Jose Maria Urtasun, Ma, Ruoyao, Farrell, Damien, Gordon, Stephen V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540498/
https://www.ncbi.nlm.nih.gov/pubmed/37770951
http://dx.doi.org/10.1186/s13620-023-00257-6
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author Mitermite, Morgane
Elizari, Jose Maria Urtasun
Ma, Ruoyao
Farrell, Damien
Gordon, Stephen V.
author_facet Mitermite, Morgane
Elizari, Jose Maria Urtasun
Ma, Ruoyao
Farrell, Damien
Gordon, Stephen V.
author_sort Mitermite, Morgane
collection PubMed
description Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.
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spelling pubmed-105404982023-09-30 Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future Mitermite, Morgane Elizari, Jose Maria Urtasun Ma, Ruoyao Farrell, Damien Gordon, Stephen V. Ir Vet J Review Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis. BioMed Central 2023-09-28 /pmc/articles/PMC10540498/ /pubmed/37770951 http://dx.doi.org/10.1186/s13620-023-00257-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mitermite, Morgane
Elizari, Jose Maria Urtasun
Ma, Ruoyao
Farrell, Damien
Gordon, Stephen V.
Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future
title Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future
title_full Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future
title_fullStr Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future
title_full_unstemmed Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future
title_short Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future
title_sort exploring virulence in mycobacterium bovis: clues from comparative genomics and perspectives for the future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540498/
https://www.ncbi.nlm.nih.gov/pubmed/37770951
http://dx.doi.org/10.1186/s13620-023-00257-6
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