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Increased reports of severe myocarditis associated with enterovirus infection in neonates, United Kingdom, 27 June 2022 to 26 April 2023

Enteroviruses are a common cause of seasonal childhood infections. The vast majority of enterovirus infections are mild and self-limiting, although neonates can sometimes develop severe disease. Myocarditis is a rare complication of enterovirus infection. Between June 2022 and April 2023, twenty cas...

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Detalles Bibliográficos
Autores principales: Singanayagam, Anika, Moore, Catherine, Froude, Susannah, Celma, Cristina, Stowe, Julia, Hani, Erjola, Ng, Khuen Foong, Muir, Peter, Roderick, Marion, Cottrell, Simon, Bibby, David F., Vipond, Barry, Gillett, Sophie, Davis, Peter J., Gibb, Jack, Barry, Mai, Harris, Phillippa, Rowley, Frances, Song, Jiao, Shankar, Ananda Giri, McMichael, Danielle, Cohen, Jonathan M., Manian, Abirami, Harvey, Ciaran, Primrose, Louise Shaw, Wilson, Stefanie, Bradley, Declan T., Paranthaman, Karthik, Beard, Stuart, Zambon, Maria, Ramsay, Mary, Saliba, Vanessa, Ladhani, Shamez, Williams, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540513/
https://www.ncbi.nlm.nih.gov/pubmed/37768558
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.39.2300313
Descripción
Sumario:Enteroviruses are a common cause of seasonal childhood infections. The vast majority of enterovirus infections are mild and self-limiting, although neonates can sometimes develop severe disease. Myocarditis is a rare complication of enterovirus infection. Between June 2022 and April 2023, twenty cases of severe neonatal enteroviral myocarditis caused by coxsackie B viruses were reported in the United Kingdom. Sixteen required critical care support and two died. Enterovirus PCR on whole blood was the most sensitive diagnostic test. We describe the initial public health investigation into this cluster and aim to raise awareness among paediatricians, laboratories and public health specialists.