A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023

A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had...

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Detalles Bibliográficos
Autores principales: Takashita, Emi, Fujisaki, Seiichiro, Morita, Hiroko, Nagata, Shiho, Miura, Hideka, Matsuura, Yuki, Yamamoto, Saya, Chiba, Shoko, Inoue, Yumiko, Minami, Iori, Yoshikawa, Sayaka, Yamazaki, Seiko, Kishida, Noriko, Nakamura, Kazuya, Shirakura, Masayuki, Watanabe, Shinji, Hasegawa, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540515/
https://www.ncbi.nlm.nih.gov/pubmed/37768560
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.39.2300501
Descripción
Sumario:A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear.

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