A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023

A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had...

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Autores principales: Takashita, Emi, Fujisaki, Seiichiro, Morita, Hiroko, Nagata, Shiho, Miura, Hideka, Matsuura, Yuki, Yamamoto, Saya, Chiba, Shoko, Inoue, Yumiko, Minami, Iori, Yoshikawa, Sayaka, Yamazaki, Seiko, Kishida, Noriko, Nakamura, Kazuya, Shirakura, Masayuki, Watanabe, Shinji, Hasegawa, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540515/
https://www.ncbi.nlm.nih.gov/pubmed/37768560
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.39.2300501
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author Takashita, Emi
Fujisaki, Seiichiro
Morita, Hiroko
Nagata, Shiho
Miura, Hideka
Matsuura, Yuki
Yamamoto, Saya
Chiba, Shoko
Inoue, Yumiko
Minami, Iori
Yoshikawa, Sayaka
Yamazaki, Seiko
Kishida, Noriko
Nakamura, Kazuya
Shirakura, Masayuki
Watanabe, Shinji
Hasegawa, Hideki
author_facet Takashita, Emi
Fujisaki, Seiichiro
Morita, Hiroko
Nagata, Shiho
Miura, Hideka
Matsuura, Yuki
Yamamoto, Saya
Chiba, Shoko
Inoue, Yumiko
Minami, Iori
Yoshikawa, Sayaka
Yamazaki, Seiko
Kishida, Noriko
Nakamura, Kazuya
Shirakura, Masayuki
Watanabe, Shinji
Hasegawa, Hideki
author_sort Takashita, Emi
collection PubMed
description A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear.
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spelling pubmed-105405152023-09-30 A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023 Takashita, Emi Fujisaki, Seiichiro Morita, Hiroko Nagata, Shiho Miura, Hideka Matsuura, Yuki Yamamoto, Saya Chiba, Shoko Inoue, Yumiko Minami, Iori Yoshikawa, Sayaka Yamazaki, Seiko Kishida, Noriko Nakamura, Kazuya Shirakura, Masayuki Watanabe, Shinji Hasegawa, Hideki Euro Surveill Rapid Communication A community cluster of influenza A(H3N2) caused by viruses with an E199G substitution in PA was detected in Nara, Japan, between February and March 2023. The three patients with these mutant viruses had not received antiviral treatment before specimen collection but patients in the same hospital had. The sequences of the mutant viruses were closely related, suggesting clonal spread in Nara. They showed reduced susceptibility to baloxavir in vitro; however, the clinical significance of the PA E199G substitution remains unclear. European Centre for Disease Prevention and Control (ECDC) 2023-09-28 /pmc/articles/PMC10540515/ /pubmed/37768560 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.39.2300501 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Takashita, Emi
Fujisaki, Seiichiro
Morita, Hiroko
Nagata, Shiho
Miura, Hideka
Matsuura, Yuki
Yamamoto, Saya
Chiba, Shoko
Inoue, Yumiko
Minami, Iori
Yoshikawa, Sayaka
Yamazaki, Seiko
Kishida, Noriko
Nakamura, Kazuya
Shirakura, Masayuki
Watanabe, Shinji
Hasegawa, Hideki
A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
title A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
title_full A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
title_fullStr A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
title_full_unstemmed A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
title_short A community cluster of influenza A(H3N2) virus infection with reduced susceptibility to baloxavir due to a PA E199G substitution in Japan, February to March 2023
title_sort community cluster of influenza a(h3n2) virus infection with reduced susceptibility to baloxavir due to a pa e199g substitution in japan, february to march 2023
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540515/
https://www.ncbi.nlm.nih.gov/pubmed/37768560
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.39.2300501
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