Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations

3′ untranslated region (3′ UTR) somatic mutations represent a largely unexplored avenue of alternative oncogenic gene dysregulation. To determine the significance of 3′ UTR mutations in disease, we identify 3′ UTR somatic variants across 185 advanced prostate tumors, discovering 14,497 single-nucleo...

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Detalles Bibliográficos
Autores principales: Schuster, Samantha L., Arora, Sonali, Wladyka, Cynthia L., Itagi, Pushpa, Corey, Lukas, Young, Dave, Stackhouse, Bethany L., Kollath, Lori, Wu, Qian V., Corey, Eva, True, Lawrence D., Ha, Gavin, Paddison, Patrick J., Hsieh, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540565/
https://www.ncbi.nlm.nih.gov/pubmed/37516102
http://dx.doi.org/10.1016/j.celrep.2023.112840

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