A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

In this study, we generated a novel library approach for high throughput de novo identification of humanized single-domain antibodies following camelid immunization. To achieve this, VHH-derived complementarity-determining regions-3 (CDR3s) obtained from an immunized llama (Lama glama) were grafted...

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Detalles Bibliográficos
Autores principales: Arras, Paul, Yoo, Han Byul, Pekar, Lukas, Schröter, Christian, Clarke, Thomas, Krah, Simon, Klewinghaus, Daniel, Siegmund, Vanessa, Evers, Andreas, Zielonka, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540653/
https://www.ncbi.nlm.nih.gov/pubmed/37766540
http://dx.doi.org/10.1080/19420862.2023.2261149

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