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Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion

BACKGROUND: The use of intervertebral cages within the interbody fusion setting is ubiquitous. Synthetic cages are predominantly manufactured using materials such as Ti and PEEK. With the advent of additive manufacturing techniques, it is now possible to spatially vary complex 3D geometric features...

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Autores principales: Johnson, James W., Gadomski, Ben, Labus, Kevin, Stewart, Holly, Nelson, Brad, Seim, Howie, Regan, Dan, von Stade, Devin, Kelly, Cambre, Horne, Phillip, Gall, Ken, Easley, Jeremiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540818/
https://www.ncbi.nlm.nih.gov/pubmed/37780834
http://dx.doi.org/10.1002/jsp2.1268
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author Johnson, James W.
Gadomski, Ben
Labus, Kevin
Stewart, Holly
Nelson, Brad
Seim, Howie
Regan, Dan
von Stade, Devin
Kelly, Cambre
Horne, Phillip
Gall, Ken
Easley, Jeremiah
author_facet Johnson, James W.
Gadomski, Ben
Labus, Kevin
Stewart, Holly
Nelson, Brad
Seim, Howie
Regan, Dan
von Stade, Devin
Kelly, Cambre
Horne, Phillip
Gall, Ken
Easley, Jeremiah
author_sort Johnson, James W.
collection PubMed
description BACKGROUND: The use of intervertebral cages within the interbody fusion setting is ubiquitous. Synthetic cages are predominantly manufactured using materials such as Ti and PEEK. With the advent of additive manufacturing techniques, it is now possible to spatially vary complex 3D geometric features within interbody devices, enabling the devices to match the stiffness of native tissue and better promote bony integration. To date, the impact of surface porosity of additively manufactured Ti interbody cages on fusion outcomes has not been investigated. Thus, the objective of this work was to determine the effect of implant endplate surface and implant body architecture of additive manufactured lattice structure titanium interbody cages on bony fusion. METHODS: Biomechanical, microcomputed tomography, static and dynamic histomorphometry, and histopathology analyses were performed on twelve functional spine units obtained from six sheep randomly allocated to body lattice or surface lattice groups. RESULTS: Nondestructive kinematic testing, microcomputed tomography analysis, and histomorphometry analyses of the functional spine units revealed positive fusion outcomes in both groups. These data revealed similar results in both groups, with the exception of bone‐in‐contact analysis, which revealed significantly improved bone‐in‐contact values in the body lattice group compared to the surface lattice group. CONCLUSION: Both additively manufactured porous titanium cage designs resulted in increased fusion outcomes as compared to PEEK interbody cage designs as illustrated by the nondestructive kinematic motion testing, static and dynamic histomorphometry, microcomputed tomography, and histopathology analyses. While both cages provided for similar functional outcomes, these data suggest boney contact with an interbody cage may be impacted by the nature of implant porosity adjacent to the vertebral endplates.
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spelling pubmed-105408182023-09-30 Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion Johnson, James W. Gadomski, Ben Labus, Kevin Stewart, Holly Nelson, Brad Seim, Howie Regan, Dan von Stade, Devin Kelly, Cambre Horne, Phillip Gall, Ken Easley, Jeremiah JOR Spine Research Articles BACKGROUND: The use of intervertebral cages within the interbody fusion setting is ubiquitous. Synthetic cages are predominantly manufactured using materials such as Ti and PEEK. With the advent of additive manufacturing techniques, it is now possible to spatially vary complex 3D geometric features within interbody devices, enabling the devices to match the stiffness of native tissue and better promote bony integration. To date, the impact of surface porosity of additively manufactured Ti interbody cages on fusion outcomes has not been investigated. Thus, the objective of this work was to determine the effect of implant endplate surface and implant body architecture of additive manufactured lattice structure titanium interbody cages on bony fusion. METHODS: Biomechanical, microcomputed tomography, static and dynamic histomorphometry, and histopathology analyses were performed on twelve functional spine units obtained from six sheep randomly allocated to body lattice or surface lattice groups. RESULTS: Nondestructive kinematic testing, microcomputed tomography analysis, and histomorphometry analyses of the functional spine units revealed positive fusion outcomes in both groups. These data revealed similar results in both groups, with the exception of bone‐in‐contact analysis, which revealed significantly improved bone‐in‐contact values in the body lattice group compared to the surface lattice group. CONCLUSION: Both additively manufactured porous titanium cage designs resulted in increased fusion outcomes as compared to PEEK interbody cage designs as illustrated by the nondestructive kinematic motion testing, static and dynamic histomorphometry, microcomputed tomography, and histopathology analyses. While both cages provided for similar functional outcomes, these data suggest boney contact with an interbody cage may be impacted by the nature of implant porosity adjacent to the vertebral endplates. John Wiley & Sons, Inc. 2023-06-10 /pmc/articles/PMC10540818/ /pubmed/37780834 http://dx.doi.org/10.1002/jsp2.1268 Text en © 2023 The Authors. JOR Spine published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Johnson, James W.
Gadomski, Ben
Labus, Kevin
Stewart, Holly
Nelson, Brad
Seim, Howie
Regan, Dan
von Stade, Devin
Kelly, Cambre
Horne, Phillip
Gall, Ken
Easley, Jeremiah
Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion
title Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion
title_full Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion
title_fullStr Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion
title_full_unstemmed Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion
title_short Novel 3D printed lattice structure titanium cages evaluated in an ovine model of interbody fusion
title_sort novel 3d printed lattice structure titanium cages evaluated in an ovine model of interbody fusion
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540818/
https://www.ncbi.nlm.nih.gov/pubmed/37780834
http://dx.doi.org/10.1002/jsp2.1268
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