Structural characterization of human urea transporters UT-A and UT-B and their inhibition

In this study, we present the structures of human urea transporters UT-A and UT-B to characterize them at molecular level and to detail the mechanism of UT-B inhibition by its selective inhibitor, UTB(inh)-14. High-resolution structures of both transporters establish the structural basis for the inh...

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Detalles Bibliográficos
Autores principales: Chi, Gamma, Dietz, Larissa, Tang, Haiping, Snee, Matthew, Scacioc, Andreea, Wang, Dong, Mckinley, Gavin, Mukhopadhyay, Shubhashish M. M., Pike, Ashley C. W., Chalk, Rod, Burgess-Brown, Nicola A., Timmermans, Jean-Pierre, van Putte, Wouter, Robinson, Carol V., Dürr, Katharina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541013/
https://www.ncbi.nlm.nih.gov/pubmed/37774028
http://dx.doi.org/10.1126/sciadv.adg8229

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