Engineered transcription-associated Cas9 targeting in eukaryotic cells

DNA targeting Class 2 CRISPR-Cas effector nucleases, including the well-studied Cas9 proteins, evolved protospacer-adjacent motif (PAM) and guide RNA interactions that sequentially license their binding and cleavage activities at protospacer target sites. Both interactions are nucleic acid sequence...

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Detalles Bibliográficos
Autores principales: Goldberg, Gregory W., Kogenaru, Manjunatha, Keegan, Sarah, Haase, Max A. B., Kagermazova, Larisa, Arias, Mauricio A., Onyebeke, Kenenna, Adams, Samantha, Fenyö, David, Noyes, Marcus B., Boeke, Jef D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541143/
https://www.ncbi.nlm.nih.gov/pubmed/37781609
http://dx.doi.org/10.1101/2023.09.18.558319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541143/
https://www.ncbi.nlm.nih.gov/pubmed/37781609
http://dx.doi.org/10.1101/2023.09.18.558319

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