RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition

Disease-initiating mutations in the transcription factor RUNX1 occur as germline and somatic events that cause leukemias with particularly poor prognosis. However, the role of RUNX1 in leukemogenesis is not fully understood, and effective therapies for RUNX1-mutant leukemias remain elusive. Here, we...

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Detalles Bibliográficos
Autores principales: Fan, Amy C., Nakauchi, Yusuke, Bai, Lawrence, Azizi, Armon, Nuno, Kevin A., Zhao, Feifei, Köhnke, Thomas, Karigane, Daiki, Cruz-Hernandez, David, Reinisch, Andreas, Khatri, Purvesh, Majeti, Ravindra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541186/
https://www.ncbi.nlm.nih.gov/pubmed/37581927
http://dx.doi.org/10.1172/JCI167053

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