Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated that lapatinib and other approved inhibitors of the...

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Detalles Bibliográficos
Autores principales: Saul, Sirle, Karim, Marwah, Ghita, Luca, Huang, Pei-Tzu, Chiu, Winston, Durán, Verónica, Lo, Chieh-Wen, Kumar, Sathish, Bhalla, Nishank, Leyssen, Pieter, Alem, Farhang, Boghdeh, Niloufar A., Tran, Do H.N., Cohen, Courtney A., Brown, Jacquelyn A., Huie, Kathleen E., Tindle, Courtney, Sibai, Mamdouh, Ye, Chengjin, Khalil, Ahmed Magdy, Chiem, Kevin, Martinez-Sobrido, Luis, Dye, John M., Pinsky, Benjamin A., Ghosh, Pradipta, Das, Soumita, Solow-Cordero, David E., Jin, Jing, Wikswo, John P., Jochmans, Dirk, Neyts, Johan, De Jonghe, Steven, Narayanan, Aarthi, Einav, Shirit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541190/
https://www.ncbi.nlm.nih.gov/pubmed/37581931
http://dx.doi.org/10.1172/JCI169510

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