HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance

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Stimulation of adipocyte β-adrenergic receptors (β-ARs) induces expression of uncoupling protein 1 (UCP1), promoting nonshivering thermogenesis. Association of β-ARs with a lysine-myristoylated form of A kinase–anchoring protein 12 (AKAP12, also known as gravin-α) is required for downstream signalin...

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Detalles Bibliográficos
Autores principales: Robinson, Emma L., Bagchi, Rushita A., Major, Jennifer L., Bergman, Bryan C., Matsuda, Jennifer L., McKinsey, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541202/
https://www.ncbi.nlm.nih.gov/pubmed/37607030
http://dx.doi.org/10.1172/JCI168192
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