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Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic
INTRODUCTION: This study aimed to investigate the effect of smoking cessation on plasma clozapine (CLO) concentrations in long-term hospitalized Chinese male patients with schizophrenia treated with CLO during the COVID-19 pandemic. METHODS: Therapeutic drug monitoring (TDM) data for CLO were collec...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541223/ https://www.ncbi.nlm.nih.gov/pubmed/37779619 http://dx.doi.org/10.3389/fpsyt.2023.1256264 |
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author | Ma, Botao Fan, Hongzhen Qi, Siyuan Yang, Fude An, Huimei |
author_facet | Ma, Botao Fan, Hongzhen Qi, Siyuan Yang, Fude An, Huimei |
author_sort | Ma, Botao |
collection | PubMed |
description | INTRODUCTION: This study aimed to investigate the effect of smoking cessation on plasma clozapine (CLO) concentrations in long-term hospitalized Chinese male patients with schizophrenia treated with CLO during the COVID-19 pandemic. METHODS: Therapeutic drug monitoring (TDM) data for CLO were collected at Beijing HuiLongGuan Hospital between December 1, 2019 (before smoking cessation) and January 31, 2020 (after smoking cessation) in this retrospective study. Fifty-three male smokers and inpatients with schizophrenia who were treated with CLO were included. Plasma concentrations of CLO were measured using high-performance liquid chromatography–tandem mass spectrometry. The fagerstrom test for nicotine dependence (FTND) was used to assess smoking behavior. RESULTS: The plasma CLO concentrations and dose-corrected plasma CLO concentrations were significantly increased by 29.3 and 23.5%, respectively, after smoking cessation. DISCUSSION: The results suggested that clinicians and pharmacists should adjust the CLO dose based on changes in smoking status in patients stabilized with CLO during the COVID-19 pandemic. Careful TDM for CLO should be performed prior to dose adjustment,to reduce the increased risk of smoking cessation induced side effects, especially for older patients receiving multiple medications. |
format | Online Article Text |
id | pubmed-10541223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105412232023-10-01 Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic Ma, Botao Fan, Hongzhen Qi, Siyuan Yang, Fude An, Huimei Front Psychiatry Psychiatry INTRODUCTION: This study aimed to investigate the effect of smoking cessation on plasma clozapine (CLO) concentrations in long-term hospitalized Chinese male patients with schizophrenia treated with CLO during the COVID-19 pandemic. METHODS: Therapeutic drug monitoring (TDM) data for CLO were collected at Beijing HuiLongGuan Hospital between December 1, 2019 (before smoking cessation) and January 31, 2020 (after smoking cessation) in this retrospective study. Fifty-three male smokers and inpatients with schizophrenia who were treated with CLO were included. Plasma concentrations of CLO were measured using high-performance liquid chromatography–tandem mass spectrometry. The fagerstrom test for nicotine dependence (FTND) was used to assess smoking behavior. RESULTS: The plasma CLO concentrations and dose-corrected plasma CLO concentrations were significantly increased by 29.3 and 23.5%, respectively, after smoking cessation. DISCUSSION: The results suggested that clinicians and pharmacists should adjust the CLO dose based on changes in smoking status in patients stabilized with CLO during the COVID-19 pandemic. Careful TDM for CLO should be performed prior to dose adjustment,to reduce the increased risk of smoking cessation induced side effects, especially for older patients receiving multiple medications. Frontiers Media S.A. 2023-09-15 /pmc/articles/PMC10541223/ /pubmed/37779619 http://dx.doi.org/10.3389/fpsyt.2023.1256264 Text en Copyright © 2023 Ma, Fan, Qi, Yang and An. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Ma, Botao Fan, Hongzhen Qi, Siyuan Yang, Fude An, Huimei Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic |
title | Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic |
title_full | Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic |
title_fullStr | Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic |
title_full_unstemmed | Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic |
title_short | Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic |
title_sort | effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the covid-19 pandemic |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541223/ https://www.ncbi.nlm.nih.gov/pubmed/37779619 http://dx.doi.org/10.3389/fpsyt.2023.1256264 |
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