A first-in-class fully modified version of miR-34a with outstanding stability, activity, and anti-tumor efficacy

Altered by defects in p53, epigenetic silencing, and genomic loss, the microRNA miR-34a represents one of the most clinically relevant tumor-suppressive microRNAs. Without question, a striking number of patients with cancer would benefit from miR-34a replacement, if poor miR-34a stability, non-speci...

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Detalles Bibliográficos
Autores principales: Abdelaal, Ahmed M., Sohal, Ikjot S., Iyer, Shreyas, Sudarshan, Kasireddy, Kothandaraman, Harish, Lanman, Nadia A., Low, Philip S., Kasinski, Andrea L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541324/
https://www.ncbi.nlm.nih.gov/pubmed/37666938
http://dx.doi.org/10.1038/s41388-023-02801-8

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