Fresh and frozen cardiac tissue are comparable in DNA methylation array β-values, but formalin-fixed, paraffin-embedded tissue may overestimate DNA methylation levels

Untreated fresh cardiac tissue is the optimal tissue material for investigating DNA methylation patterns of cardiac biology and diseases. However, fresh tissue is difficult to obtain. Therefore, tissue stored as frozen or formalin-fixed, paraffin-embedded (FFPE) is widely used for DNA methylation st...

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Detalles Bibliográficos
Autores principales: Dupont, Mikkel Eriksen, Jacobsen, Stine Bøttcher, Christiansen, Steffan Noe Niikanoff, Tfelt-Hansen, Jacob, Smerup, Morten Holdgaard, Andersen, Jeppe Dyrberg, Morling, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541404/
https://www.ncbi.nlm.nih.gov/pubmed/37773256
http://dx.doi.org/10.1038/s41598-023-43788-2

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