An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformational equilibrium between an open and a pre-existing lowly p...

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Detalles Bibliográficos
Autores principales: Cui, Gaofeng, Botuyan, Maria Victoria, Drané, Pascal, Hu, Qi, Bragantini, Benoît, Thompson, James R., Schuller, David J., Detappe, Alexandre, Perfetti, Michael T., James, Lindsey I., Frye, Stephen V., Chowdhury, Dipanjan, Mer, Georges
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541411/
https://www.ncbi.nlm.nih.gov/pubmed/37773238
http://dx.doi.org/10.1038/s41467-023-41821-6

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