POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis

Protection of telomeres 1a (POT1a) is a telomere binding protein. A decrease of POT1a is related to myeloid-skewed haematopoiesis with ageing, suggesting that protection of telomeres is essential to sustain multi-potency. Since mesenchymal stem cells (MSCs) are a constituent of the hematopoietic nic...

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Detalles Bibliográficos
Autores principales: Nakashima, Kentaro, Kunisaki, Yuya, Hosokawa, Kentaro, Gotoh, Kazuhito, Yao, Hisayuki, Yuta, Ryosuke, Semba, Yuichiro, Nogami, Jumpei, Kikushige, Yoshikane, Stumpf, Patrick S., MacArthur, Ben D., Kang, Dongchon, Akashi, Koichi, Ohga, Shouichi, Arai, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541440/
https://www.ncbi.nlm.nih.gov/pubmed/37773433
http://dx.doi.org/10.1038/s42003-023-05374-0

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