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New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities or disruptions in electrical conduction, lead to arrhythmic disorders may be benign, typical, threatening, ultimately fatal, occurs in clinical practice, patients on digitalis, anaesthesia or acute myocardial...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541452/ https://www.ncbi.nlm.nih.gov/pubmed/37775650 http://dx.doi.org/10.1038/s41598-023-41942-4 |
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author | Sharma, Ashish Kumar Singh, Shivam Bhat, Mehvish Gill, Kartik Zaid, Mohammad Kumar, Sachin Shakya, Anjali Tantray, Junaid Jose, Divyamol Gupta, Rashmi Yangzom, Tsering Sharma, Rajesh Kumar Sahu, Sanjay Kumar Rathore, Gulshan Chandolia, Priyanka Singh, Mithilesh Mishra, Anurag Raj, Shobhit Gupta, Archita Agarwal, Mohit Kifayat, Sumaiya Gupta, Anamika Gupta, Prashant Vashist, Ankit Vaibhav, Parth Kathuria, Nancy Yadav, Vipin Singh, Ravindra Pal Garg, Arun |
author_facet | Sharma, Ashish Kumar Singh, Shivam Bhat, Mehvish Gill, Kartik Zaid, Mohammad Kumar, Sachin Shakya, Anjali Tantray, Junaid Jose, Divyamol Gupta, Rashmi Yangzom, Tsering Sharma, Rajesh Kumar Sahu, Sanjay Kumar Rathore, Gulshan Chandolia, Priyanka Singh, Mithilesh Mishra, Anurag Raj, Shobhit Gupta, Archita Agarwal, Mohit Kifayat, Sumaiya Gupta, Anamika Gupta, Prashant Vashist, Ankit Vaibhav, Parth Kathuria, Nancy Yadav, Vipin Singh, Ravindra Pal Garg, Arun |
author_sort | Sharma, Ashish Kumar |
collection | PubMed |
description | Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities or disruptions in electrical conduction, lead to arrhythmic disorders may be benign, typical, threatening, ultimately fatal, occurs in clinical practice, patients on digitalis, anaesthesia or acute myocardial infarction. Both traditional and genetic animal models are: In-vitro: Isolated ventricular Myocytes, Guinea pig papillary muscles, Patch-Clamp Experiments, Porcine Atrial Myocytes, Guinea pig ventricular myocytes, Guinea pig papillary muscle: action potential and refractory period, Langendorff technique, Arrhythmia by acetylcholine or potassium. Acquired arrhythmia disorders: Transverse Aortic Constriction, Myocardial Ischemia, Complete Heart Block and AV Node Ablation, Chronic Tachypacing, Inflammation, Metabolic and Drug-Induced Arrhythmia. In-Vivo: Chemically induced arrhythmia: Aconitine antagonism, Digoxin-induced arrhythmia, Strophanthin/ouabain-induced arrhythmia, Adrenaline-induced arrhythmia, and Calcium-induced arrhythmia. Electrically induced arrhythmia: Ventricular fibrillation electrical threshold, Arrhythmia through programmed electrical stimulation, sudden coronary death in dogs, Exercise ventricular fibrillation. Genetic Arrhythmia: Channelopathies, Calcium Release Deficiency Syndrome, Long QT Syndrome, Short QT Syndrome, Brugada Syndrome. Genetic with Structural Heart Disease: Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Atrial Fibrillation, Sick Sinus Syndrome, Atrioventricular Block, Preexcitation Syndrome. Arrhythmia in Pluripotent Stem Cell Cardiomyocytes. Conclusion: Both traditional and genetic, experimental models of cardiac arrhythmias’ characteristics and significance help in development of new antiarrhythmic drugs. |
format | Online Article Text |
id | pubmed-10541452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105414522023-10-01 New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models Sharma, Ashish Kumar Singh, Shivam Bhat, Mehvish Gill, Kartik Zaid, Mohammad Kumar, Sachin Shakya, Anjali Tantray, Junaid Jose, Divyamol Gupta, Rashmi Yangzom, Tsering Sharma, Rajesh Kumar Sahu, Sanjay Kumar Rathore, Gulshan Chandolia, Priyanka Singh, Mithilesh Mishra, Anurag Raj, Shobhit Gupta, Archita Agarwal, Mohit Kifayat, Sumaiya Gupta, Anamika Gupta, Prashant Vashist, Ankit Vaibhav, Parth Kathuria, Nancy Yadav, Vipin Singh, Ravindra Pal Garg, Arun Sci Rep Article Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker abnormalities or disruptions in electrical conduction, lead to arrhythmic disorders may be benign, typical, threatening, ultimately fatal, occurs in clinical practice, patients on digitalis, anaesthesia or acute myocardial infarction. Both traditional and genetic animal models are: In-vitro: Isolated ventricular Myocytes, Guinea pig papillary muscles, Patch-Clamp Experiments, Porcine Atrial Myocytes, Guinea pig ventricular myocytes, Guinea pig papillary muscle: action potential and refractory period, Langendorff technique, Arrhythmia by acetylcholine or potassium. Acquired arrhythmia disorders: Transverse Aortic Constriction, Myocardial Ischemia, Complete Heart Block and AV Node Ablation, Chronic Tachypacing, Inflammation, Metabolic and Drug-Induced Arrhythmia. In-Vivo: Chemically induced arrhythmia: Aconitine antagonism, Digoxin-induced arrhythmia, Strophanthin/ouabain-induced arrhythmia, Adrenaline-induced arrhythmia, and Calcium-induced arrhythmia. Electrically induced arrhythmia: Ventricular fibrillation electrical threshold, Arrhythmia through programmed electrical stimulation, sudden coronary death in dogs, Exercise ventricular fibrillation. Genetic Arrhythmia: Channelopathies, Calcium Release Deficiency Syndrome, Long QT Syndrome, Short QT Syndrome, Brugada Syndrome. Genetic with Structural Heart Disease: Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Atrial Fibrillation, Sick Sinus Syndrome, Atrioventricular Block, Preexcitation Syndrome. Arrhythmia in Pluripotent Stem Cell Cardiomyocytes. Conclusion: Both traditional and genetic, experimental models of cardiac arrhythmias’ characteristics and significance help in development of new antiarrhythmic drugs. Nature Publishing Group UK 2023-09-29 /pmc/articles/PMC10541452/ /pubmed/37775650 http://dx.doi.org/10.1038/s41598-023-41942-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sharma, Ashish Kumar Singh, Shivam Bhat, Mehvish Gill, Kartik Zaid, Mohammad Kumar, Sachin Shakya, Anjali Tantray, Junaid Jose, Divyamol Gupta, Rashmi Yangzom, Tsering Sharma, Rajesh Kumar Sahu, Sanjay Kumar Rathore, Gulshan Chandolia, Priyanka Singh, Mithilesh Mishra, Anurag Raj, Shobhit Gupta, Archita Agarwal, Mohit Kifayat, Sumaiya Gupta, Anamika Gupta, Prashant Vashist, Ankit Vaibhav, Parth Kathuria, Nancy Yadav, Vipin Singh, Ravindra Pal Garg, Arun New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models |
title | New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models |
title_full | New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models |
title_fullStr | New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models |
title_full_unstemmed | New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models |
title_short | New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models |
title_sort | new drug discovery of cardiac anti-arrhythmic drugs: insights in animal models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541452/ https://www.ncbi.nlm.nih.gov/pubmed/37775650 http://dx.doi.org/10.1038/s41598-023-41942-4 |
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