Cargando…
The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy
OBJECTIVE: Bladder cancer is a heterogeneous entity characterized by a wide range of different morphologies. The aim of this study was to investigate the prognostic effect of bladder tumor with variant histology that is treated with radical cystectomy on oncological outcomes. METHODS: One hundred ei...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Turkish Association of Urology
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541520/ https://www.ncbi.nlm.nih.gov/pubmed/37877826 http://dx.doi.org/10.5152/tud.2023.22223 |
_version_ | 1785113918838931456 |
---|---|
author | Efiloğlu, Özgür Çakıcı, Mehmet Çağlar Kır, Gözde İplikçi, Ayberk Turan, Turgay Cecikoğlu, Gözde Ecem Yıldırım, Asıf |
author_facet | Efiloğlu, Özgür Çakıcı, Mehmet Çağlar Kır, Gözde İplikçi, Ayberk Turan, Turgay Cecikoğlu, Gözde Ecem Yıldırım, Asıf |
author_sort | Efiloğlu, Özgür |
collection | PubMed |
description | OBJECTIVE: Bladder cancer is a heterogeneous entity characterized by a wide range of different morphologies. The aim of this study was to investigate the prognostic effect of bladder tumor with variant histology that is treated with radical cystectomy on oncological outcomes. METHODS: One hundred eighty-six patients who underwent radical cystectomy between September 2001 and June 2020 were included in the study. The patients were divided into 2 groups variant histology group (n = 54) and transitional cell cancer group (n = 132). Clinicopathologic data were compared between the two groups. RESULTS: The groups were similar in terms of demographic characteristics. In the multivariate analysis of cancer-specific survival in transitional cell cancer against variant histology, high-grade detection of primary transurethral bladder tumor pathology, cystectomy pT, cystectomy positive lymph node, and positive surgical margin in cystectomy were determined to be statistically significant. Diagnosis of pT2 and high grade of primary transurethral bladder tumor pathology, cystectomy ≥ pT3, cystectomy positive lymph node, and positive surgical margin in cystectomy were statistically significant in multivariate analysis of overall survival. Cancer-specific survival time was estimated at 65.1 ± 8.3 months for variant histology and 134.2 ± 10.4 months for transitional cell cancer (P = .004). The estimated overall survival time was 61.9 ± 8.0 months in variant histology and 119.0 ± 9.8 months in transitional cell cancer (P = .014). CONCLUSION: Pathological features and prognosis of bladder cancer with variant histologies are worse than those of pure urothelial bladder cancer. Overall survival and cancer-specific survival are shorter in bladder cancer with variant histology than in pure urothelial bladder cancer. Following the diagnosis of variant histology in transurethral bladder tumor, poor prognosis must be considered in the treatment plan. |
format | Online Article Text |
id | pubmed-10541520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Turkish Association of Urology |
record_format | MEDLINE/PubMed |
spelling | pubmed-105415202023-10-02 The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy Efiloğlu, Özgür Çakıcı, Mehmet Çağlar Kır, Gözde İplikçi, Ayberk Turan, Turgay Cecikoğlu, Gözde Ecem Yıldırım, Asıf Urol Res Pract Original Article OBJECTIVE: Bladder cancer is a heterogeneous entity characterized by a wide range of different morphologies. The aim of this study was to investigate the prognostic effect of bladder tumor with variant histology that is treated with radical cystectomy on oncological outcomes. METHODS: One hundred eighty-six patients who underwent radical cystectomy between September 2001 and June 2020 were included in the study. The patients were divided into 2 groups variant histology group (n = 54) and transitional cell cancer group (n = 132). Clinicopathologic data were compared between the two groups. RESULTS: The groups were similar in terms of demographic characteristics. In the multivariate analysis of cancer-specific survival in transitional cell cancer against variant histology, high-grade detection of primary transurethral bladder tumor pathology, cystectomy pT, cystectomy positive lymph node, and positive surgical margin in cystectomy were determined to be statistically significant. Diagnosis of pT2 and high grade of primary transurethral bladder tumor pathology, cystectomy ≥ pT3, cystectomy positive lymph node, and positive surgical margin in cystectomy were statistically significant in multivariate analysis of overall survival. Cancer-specific survival time was estimated at 65.1 ± 8.3 months for variant histology and 134.2 ± 10.4 months for transitional cell cancer (P = .004). The estimated overall survival time was 61.9 ± 8.0 months in variant histology and 119.0 ± 9.8 months in transitional cell cancer (P = .014). CONCLUSION: Pathological features and prognosis of bladder cancer with variant histologies are worse than those of pure urothelial bladder cancer. Overall survival and cancer-specific survival are shorter in bladder cancer with variant histology than in pure urothelial bladder cancer. Following the diagnosis of variant histology in transurethral bladder tumor, poor prognosis must be considered in the treatment plan. Turkish Association of Urology 2023-07-01 /pmc/articles/PMC10541520/ /pubmed/37877826 http://dx.doi.org/10.5152/tud.2023.22223 Text en 2023 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Original Article Efiloğlu, Özgür Çakıcı, Mehmet Çağlar Kır, Gözde İplikçi, Ayberk Turan, Turgay Cecikoğlu, Gözde Ecem Yıldırım, Asıf The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy |
title | The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy |
title_full | The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy |
title_fullStr | The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy |
title_full_unstemmed | The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy |
title_short | The Impact of Histological Variants on Oncological Outcomes in Patients with Muscle Invasive Bladder Cancer Treated with Radical Cystectomy |
title_sort | impact of histological variants on oncological outcomes in patients with muscle invasive bladder cancer treated with radical cystectomy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541520/ https://www.ncbi.nlm.nih.gov/pubmed/37877826 http://dx.doi.org/10.5152/tud.2023.22223 |
work_keys_str_mv | AT efilogluozgur theimpactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT cakıcımehmetcaglar theimpactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT kırgozde theimpactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT iplikciayberk theimpactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT turanturgay theimpactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT cecikoglugozdeecem theimpactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT yıldırımasıf theimpactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT efilogluozgur impactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT cakıcımehmetcaglar impactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT kırgozde impactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT iplikciayberk impactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT turanturgay impactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT cecikoglugozdeecem impactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy AT yıldırımasıf impactofhistologicalvariantsononcologicaloutcomesinpatientswithmuscleinvasivebladdercancertreatedwithradicalcystectomy |