Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization

Enhancers possess both structural elements mediating promoter looping and functional elements mediating gene expression. Traditional models of enhancer-mediated gene regulation imply genomic overlap or immediate adjacency of these elements. We test this model by combining densely-tiled CRISPRa scree...

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Detalles Bibliográficos
Autores principales: Cerda-Smith, Christian G., Hutchinson, Haley M., Liu, Annie, Goel, Viraat Y., Sept, Corriene, Kim, Holly, Casaní-Galdón, Salvador, Burkman, Katherine G., Bassil, Christopher F., Hansen, Anders S., Aryee, Martin J., Johnstone, Sarah E., Eyler, Christine E., Wood, Kris C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541578/
https://www.ncbi.nlm.nih.gov/pubmed/37786671
http://dx.doi.org/10.1101/2023.09.20.558459

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