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Depleting glioblastoma cells of very long-chain acyl-CoA synthetase 3 (ACSVL3) produces metabolic alterations in non-lipid pathways

Knockout (KO) of the fatty acid-activation enzyme very long-chain acyl-CoA synthetase 3 (ACSVL3; SLC27A3) in U87MG glioblastoma cells reduced their malignant growth properties both in vitro and in xenografts. These U87-KO glioma cells grew at a slower rate, became adherence-dependent, and were less...

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Detalles Bibliográficos
Autores principales:	Kolar, Elizabeth A., Shi, Xiaohai, Clay, Emily M., Liu, Yanqiu, Xia, Shuli, Zhang, Cissy, Le, Anne, Watkins, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541593/ https://www.ncbi.nlm.nih.gov/pubmed/37786718 http://dx.doi.org/10.1101/2023.09.18.558236

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