Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen

MITF, a basic-Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. To explore MITF regulation and its role in melanoma, we conducted a genetic screen for suppressors of the Mitf-associated pigmentation phenotype. An intrage...

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Detalles Bibliográficos
Autores principales: Vu, Hong Nhung, Valdimarsson, Matti Már, Sigurbjörnsdóttir, Sara, Bergsteinsdóttir, Kristín, Debbache, Julien, Bismuth, Keren, Swing, Deborah A., Hallsson, Jón H., Larue, Lionel, Arnheiter, Heinz, Copeland, Neal G., Jenkins, Nancy A., Heidarsson, Petur O., Steingrímsson, Eiríkur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541597/
https://www.ncbi.nlm.nih.gov/pubmed/37786677
http://dx.doi.org/10.1101/2023.08.04.551952

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