Investigating the conformational landscape of AlphaFold2-predicted protein kinase structures

SUMMARY: Protein kinases are a family of signaling proteins, crucial for maintaining cellular homeostasis. When dysregulated, kinases drive the pathogenesis of several diseases, and are thus one of the largest target categories for drug discovery. Kinase activity is tightly controlled by switching t...

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Detalles Bibliográficos
Autores principales: Al-Masri, Carmen, Trozzi, Francesco, Lin, Shu-Hang, Tran, Oanh, Sahni, Navriti, Patek, Marcel, Cichonska, Anna, Ravikumar, Balaguru, Rahman, Rayees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541651/
https://www.ncbi.nlm.nih.gov/pubmed/37786533
http://dx.doi.org/10.1093/bioadv/vbad129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541651/
https://www.ncbi.nlm.nih.gov/pubmed/37786533
http://dx.doi.org/10.1093/bioadv/vbad129

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