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Investigating the conformational landscape of AlphaFold2-predicted protein kinase structures
SUMMARY: Protein kinases are a family of signaling proteins, crucial for maintaining cellular homeostasis. When dysregulated, kinases drive the pathogenesis of several diseases, and are thus one of the largest target categories for drug discovery. Kinase activity is tightly controlled by switching t...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541651/ https://www.ncbi.nlm.nih.gov/pubmed/37786533 http://dx.doi.org/10.1093/bioadv/vbad129 |